Cargando…

Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction

Olfactory dysfunction (OD) is a common symptom in coronavirus disease 2019 (COVID-19) patients. Moreover, many neurological manifestations have been reported in these patients, suggesting central nervous system involvement. The default mode network (DMN) is closely associated with olfactory processi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hui, Chung, Tom Wai-Hin, Wong, Fergus Kai-Chuen, Hung, Ivan Fan-Ngai, Mak, Henry Ka-Fung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029634/
https://www.ncbi.nlm.nih.gov/pubmed/35448042
http://dx.doi.org/10.3390/brainsci12040511
_version_ 1784691928085823488
author Zhang, Hui
Chung, Tom Wai-Hin
Wong, Fergus Kai-Chuen
Hung, Ivan Fan-Ngai
Mak, Henry Ka-Fung
author_facet Zhang, Hui
Chung, Tom Wai-Hin
Wong, Fergus Kai-Chuen
Hung, Ivan Fan-Ngai
Mak, Henry Ka-Fung
author_sort Zhang, Hui
collection PubMed
description Olfactory dysfunction (OD) is a common symptom in coronavirus disease 2019 (COVID-19) patients. Moreover, many neurological manifestations have been reported in these patients, suggesting central nervous system involvement. The default mode network (DMN) is closely associated with olfactory processing. In this study, we investigated the internetwork and intranetwork connectivity of the DMN and the olfactory network (ON) in 13 healthy controls and 22 patients presenting with COVID-19-related OD using independent component analysis and region of interest functional magnetic resonance imaging (fMRI) analysis. There was a significant correlation between the butanol threshold test (BTT) and the intranetwork connectivity in ON. Meanwhile, the COVID-19 patients with OD showed significantly higher intranetwork connectivity in the DMN, as well as higher internetwork connectivity between ON and DMN. However, no significant difference was found between groups in the intranetwork connectivity within ON. We postulate that higher intranetwork functional connectivities compensate for the deficits in olfactory processing and general well-being in COVID-19 patients. Nevertheless, the compensation process in the ON may not be obvious at this stage. Our results suggest that resting-state fMRI is a potentially valuable tool to evaluate neurosensory dysfunction in COVID-19 patients.
format Online
Article
Text
id pubmed-9029634
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90296342022-04-23 Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction Zhang, Hui Chung, Tom Wai-Hin Wong, Fergus Kai-Chuen Hung, Ivan Fan-Ngai Mak, Henry Ka-Fung Brain Sci Article Olfactory dysfunction (OD) is a common symptom in coronavirus disease 2019 (COVID-19) patients. Moreover, many neurological manifestations have been reported in these patients, suggesting central nervous system involvement. The default mode network (DMN) is closely associated with olfactory processing. In this study, we investigated the internetwork and intranetwork connectivity of the DMN and the olfactory network (ON) in 13 healthy controls and 22 patients presenting with COVID-19-related OD using independent component analysis and region of interest functional magnetic resonance imaging (fMRI) analysis. There was a significant correlation between the butanol threshold test (BTT) and the intranetwork connectivity in ON. Meanwhile, the COVID-19 patients with OD showed significantly higher intranetwork connectivity in the DMN, as well as higher internetwork connectivity between ON and DMN. However, no significant difference was found between groups in the intranetwork connectivity within ON. We postulate that higher intranetwork functional connectivities compensate for the deficits in olfactory processing and general well-being in COVID-19 patients. Nevertheless, the compensation process in the ON may not be obvious at this stage. Our results suggest that resting-state fMRI is a potentially valuable tool to evaluate neurosensory dysfunction in COVID-19 patients. MDPI 2022-04-18 /pmc/articles/PMC9029634/ /pubmed/35448042 http://dx.doi.org/10.3390/brainsci12040511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Hui
Chung, Tom Wai-Hin
Wong, Fergus Kai-Chuen
Hung, Ivan Fan-Ngai
Mak, Henry Ka-Fung
Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction
title Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction
title_full Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction
title_fullStr Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction
title_full_unstemmed Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction
title_short Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction
title_sort changes in the intranetwork and internetwork connectivity of the default mode network and olfactory network in patients with covid-19 and olfactory dysfunction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029634/
https://www.ncbi.nlm.nih.gov/pubmed/35448042
http://dx.doi.org/10.3390/brainsci12040511
work_keys_str_mv AT zhanghui changesintheintranetworkandinternetworkconnectivityofthedefaultmodenetworkandolfactorynetworkinpatientswithcovid19andolfactorydysfunction
AT chungtomwaihin changesintheintranetworkandinternetworkconnectivityofthedefaultmodenetworkandolfactorynetworkinpatientswithcovid19andolfactorydysfunction
AT wongferguskaichuen changesintheintranetworkandinternetworkconnectivityofthedefaultmodenetworkandolfactorynetworkinpatientswithcovid19andolfactorydysfunction
AT hungivanfanngai changesintheintranetworkandinternetworkconnectivityofthedefaultmodenetworkandolfactorynetworkinpatientswithcovid19andolfactorydysfunction
AT makhenrykafung changesintheintranetworkandinternetworkconnectivityofthedefaultmodenetworkandolfactorynetworkinpatientswithcovid19andolfactorydysfunction