5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study

2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia gravis. 5-Aryl-1,3,4-oxadiazoles decorated wit...

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Detalles Bibliográficos
Autores principales: Pflégr, Václav, Štěpánková, Šárka, Svrčková, Katarína, Švarcová, Markéta, Vinšová, Jarmila, Krátký, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029695/
https://www.ncbi.nlm.nih.gov/pubmed/35455397
http://dx.doi.org/10.3390/ph15040400

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