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Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Background: Cervical dysplasia persistence/recurrence has a great impact on women’s health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. Methods: This is a retrospective multi-institutional study based on chart...

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Autores principales: Bogani, Giorgio, Lalli, Luca, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell’Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Palaia, Innocenza, Perniola, Giorgia, Fischetti, Margherita, Santangelo, Giusi, Fracassi, Alice, D’Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G., Cianci, Antonio, Cianci, Stefano, Bosio, Sara, Ruisi, Simona, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa, Zannoni, Gian Franco, Ferrandina, Gabriella, Petrillo, Marco, Capobianco, Giampiero, Dessiole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Muschiato, Barbara, Palomba, Stefano, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Angioli, Roberto, Benedetti Panici, Pierluigi, Muzii, Ludovico, Scambia, Giovanni, Raspagliesi, Francesco, Di Donato, Violante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029732/
https://www.ncbi.nlm.nih.gov/pubmed/35455328
http://dx.doi.org/10.3390/vaccines10040579
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author Bogani, Giorgio
Lalli, Luca
Sopracordevole, Francesco
Ciavattini, Andrea
Ghelardi, Alessandro
Simoncini, Tommaso
Plotti, Francesco
Casarin, Jvan
Serati, Maurizio
Pinelli, Ciro
Bergamini, Alice
Gardella, Barbara
Dell’Acqua, Andrea
Monti, Ermelinda
Vercellini, Paolo
Palaia, Innocenza
Perniola, Giorgia
Fischetti, Margherita
Santangelo, Giusi
Fracassi, Alice
D’Ippolito, Giovanni
Aguzzoli, Lorenzo
Mandato, Vincenzo Dario
Giannella, Luca
Scaffa, Cono
Falcone, Francesca
Borghi, Chiara
Malzoni, Mario
Giannini, Andrea
Salerno, Maria Giovanna
Liberale, Viola
Contino, Biagio
Donfrancesco, Cristina
Desiato, Michele
Perrone, Anna Myriam
Dondi, Giulia
De Iaco, Pierandrea
Ferrero, Simone
Sarpietro, Giuseppe
Matarazzo, Maria G.
Cianci, Antonio
Cianci, Stefano
Bosio, Sara
Ruisi, Simona
Mosca, Lavinia
Tinelli, Raffaele
De Vincenzo, Rosa
Zannoni, Gian Franco
Ferrandina, Gabriella
Petrillo, Marco
Capobianco, Giampiero
Dessiole, Salvatore
Carlea, Annunziata
Zullo, Fulvio
Muschiato, Barbara
Palomba, Stefano
Greggi, Stefano
Spinillo, Arsenio
Ghezzi, Fabio
Colacurci, Nicola
Angioli, Roberto
Benedetti Panici, Pierluigi
Muzii, Ludovico
Scambia, Giovanni
Raspagliesi, Francesco
Di Donato, Violante
author_facet Bogani, Giorgio
Lalli, Luca
Sopracordevole, Francesco
Ciavattini, Andrea
Ghelardi, Alessandro
Simoncini, Tommaso
Plotti, Francesco
Casarin, Jvan
Serati, Maurizio
Pinelli, Ciro
Bergamini, Alice
Gardella, Barbara
Dell’Acqua, Andrea
Monti, Ermelinda
Vercellini, Paolo
Palaia, Innocenza
Perniola, Giorgia
Fischetti, Margherita
Santangelo, Giusi
Fracassi, Alice
D’Ippolito, Giovanni
Aguzzoli, Lorenzo
Mandato, Vincenzo Dario
Giannella, Luca
Scaffa, Cono
Falcone, Francesca
Borghi, Chiara
Malzoni, Mario
Giannini, Andrea
Salerno, Maria Giovanna
Liberale, Viola
Contino, Biagio
Donfrancesco, Cristina
Desiato, Michele
Perrone, Anna Myriam
Dondi, Giulia
De Iaco, Pierandrea
Ferrero, Simone
Sarpietro, Giuseppe
Matarazzo, Maria G.
Cianci, Antonio
Cianci, Stefano
Bosio, Sara
Ruisi, Simona
Mosca, Lavinia
Tinelli, Raffaele
De Vincenzo, Rosa
Zannoni, Gian Franco
Ferrandina, Gabriella
Petrillo, Marco
Capobianco, Giampiero
Dessiole, Salvatore
Carlea, Annunziata
Zullo, Fulvio
Muschiato, Barbara
Palomba, Stefano
Greggi, Stefano
Spinillo, Arsenio
Ghezzi, Fabio
Colacurci, Nicola
Angioli, Roberto
Benedetti Panici, Pierluigi
Muzii, Ludovico
Scambia, Giovanni
Raspagliesi, Francesco
Di Donato, Violante
author_sort Bogani, Giorgio
collection PubMed
description Background: Cervical dysplasia persistence/recurrence has a great impact on women’s health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. Methods: This is a retrospective multi-institutional study based on charts of consecutive patients undergoing conization between 1 January 2010 and 31 December 2014. A nomogram assessing the importance of different variables was built. A cohort of patients treated between 1 January 2015 and 30 June 2016 was used to validate the nomogram. Results: A total of 2966 patients undergoing primary conization were analyzed. The median (range) patient age was 40 (18–89) years. At 5-year of follow-up, 6% of patients (175/2966) had developed a persistent/recurrent cervical dysplasia. Median (range) recurrence-free survival was 18 (5–52) months. Diagnosis of CIN3, presence of HR-HPV types, positive endocervical margins, HPV persistence, and the omission of HPV vaccination after conization increased significantly and independently of the risk of developing cervical dysplasia persistence/recurrence. A nomogram weighting the impact of all variables was built with a C-Index of 0.809. A dataset of 549 patients was used to validate the nomogram, with a C-index of 0.809. Conclusions: The present nomogram represents a useful tool for counseling women about their risk of persistence/recurrence after primary conization. HPV vaccination after conization is associated with a reduced risk of CIN2+.
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spelling pubmed-90297322022-04-23 Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia Bogani, Giorgio Lalli, Luca Sopracordevole, Francesco Ciavattini, Andrea Ghelardi, Alessandro Simoncini, Tommaso Plotti, Francesco Casarin, Jvan Serati, Maurizio Pinelli, Ciro Bergamini, Alice Gardella, Barbara Dell’Acqua, Andrea Monti, Ermelinda Vercellini, Paolo Palaia, Innocenza Perniola, Giorgia Fischetti, Margherita Santangelo, Giusi Fracassi, Alice D’Ippolito, Giovanni Aguzzoli, Lorenzo Mandato, Vincenzo Dario Giannella, Luca Scaffa, Cono Falcone, Francesca Borghi, Chiara Malzoni, Mario Giannini, Andrea Salerno, Maria Giovanna Liberale, Viola Contino, Biagio Donfrancesco, Cristina Desiato, Michele Perrone, Anna Myriam Dondi, Giulia De Iaco, Pierandrea Ferrero, Simone Sarpietro, Giuseppe Matarazzo, Maria G. Cianci, Antonio Cianci, Stefano Bosio, Sara Ruisi, Simona Mosca, Lavinia Tinelli, Raffaele De Vincenzo, Rosa Zannoni, Gian Franco Ferrandina, Gabriella Petrillo, Marco Capobianco, Giampiero Dessiole, Salvatore Carlea, Annunziata Zullo, Fulvio Muschiato, Barbara Palomba, Stefano Greggi, Stefano Spinillo, Arsenio Ghezzi, Fabio Colacurci, Nicola Angioli, Roberto Benedetti Panici, Pierluigi Muzii, Ludovico Scambia, Giovanni Raspagliesi, Francesco Di Donato, Violante Vaccines (Basel) Article Background: Cervical dysplasia persistence/recurrence has a great impact on women’s health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. Methods: This is a retrospective multi-institutional study based on charts of consecutive patients undergoing conization between 1 January 2010 and 31 December 2014. A nomogram assessing the importance of different variables was built. A cohort of patients treated between 1 January 2015 and 30 June 2016 was used to validate the nomogram. Results: A total of 2966 patients undergoing primary conization were analyzed. The median (range) patient age was 40 (18–89) years. At 5-year of follow-up, 6% of patients (175/2966) had developed a persistent/recurrent cervical dysplasia. Median (range) recurrence-free survival was 18 (5–52) months. Diagnosis of CIN3, presence of HR-HPV types, positive endocervical margins, HPV persistence, and the omission of HPV vaccination after conization increased significantly and independently of the risk of developing cervical dysplasia persistence/recurrence. A nomogram weighting the impact of all variables was built with a C-Index of 0.809. A dataset of 549 patients was used to validate the nomogram, with a C-index of 0.809. Conclusions: The present nomogram represents a useful tool for counseling women about their risk of persistence/recurrence after primary conization. HPV vaccination after conization is associated with a reduced risk of CIN2+. MDPI 2022-04-09 /pmc/articles/PMC9029732/ /pubmed/35455328 http://dx.doi.org/10.3390/vaccines10040579 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bogani, Giorgio
Lalli, Luca
Sopracordevole, Francesco
Ciavattini, Andrea
Ghelardi, Alessandro
Simoncini, Tommaso
Plotti, Francesco
Casarin, Jvan
Serati, Maurizio
Pinelli, Ciro
Bergamini, Alice
Gardella, Barbara
Dell’Acqua, Andrea
Monti, Ermelinda
Vercellini, Paolo
Palaia, Innocenza
Perniola, Giorgia
Fischetti, Margherita
Santangelo, Giusi
Fracassi, Alice
D’Ippolito, Giovanni
Aguzzoli, Lorenzo
Mandato, Vincenzo Dario
Giannella, Luca
Scaffa, Cono
Falcone, Francesca
Borghi, Chiara
Malzoni, Mario
Giannini, Andrea
Salerno, Maria Giovanna
Liberale, Viola
Contino, Biagio
Donfrancesco, Cristina
Desiato, Michele
Perrone, Anna Myriam
Dondi, Giulia
De Iaco, Pierandrea
Ferrero, Simone
Sarpietro, Giuseppe
Matarazzo, Maria G.
Cianci, Antonio
Cianci, Stefano
Bosio, Sara
Ruisi, Simona
Mosca, Lavinia
Tinelli, Raffaele
De Vincenzo, Rosa
Zannoni, Gian Franco
Ferrandina, Gabriella
Petrillo, Marco
Capobianco, Giampiero
Dessiole, Salvatore
Carlea, Annunziata
Zullo, Fulvio
Muschiato, Barbara
Palomba, Stefano
Greggi, Stefano
Spinillo, Arsenio
Ghezzi, Fabio
Colacurci, Nicola
Angioli, Roberto
Benedetti Panici, Pierluigi
Muzii, Ludovico
Scambia, Giovanni
Raspagliesi, Francesco
Di Donato, Violante
Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia
title Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia
title_full Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia
title_fullStr Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia
title_full_unstemmed Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia
title_short Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia
title_sort development of a nomogram predicting the risk of persistence/recurrence of cervical dysplasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029732/
https://www.ncbi.nlm.nih.gov/pubmed/35455328
http://dx.doi.org/10.3390/vaccines10040579
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