Cargando…

Predictive Modeling of Alzheimer’s and Parkinson’s Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid

In recent years, metabolomics has been used as a powerful tool to better understand the physiology of neurodegenerative diseases and identify potential biomarkers for progression. We used targeted and untargeted aqueous, and lipidomic profiles of the metabolome from human cerebrospinal fluid to buil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwangbo, Nathan, Zhang, Xinyu, Raftery, Daniel, Gu, Haiwei, Hu, Shu-Ching, Montine, Thomas J., Quinn, Joseph F., Chung, Kathryn A., Hiller, Amie L., Wang, Dongfang, Fei, Qiang, Bettcher, Lisa, Zabetian, Cyrus P., Peskind, Elaine R., Li, Ge, Promislow, Daniel E. L., Davis, Marie Y., Franks, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029812/ https://www.ncbi.nlm.nih.gov/pubmed/35448464 http://dx.doi.org/10.3390/metabo12040277

Ejemplares similares

Cerebrospinal Fluid Metabolomics: Pilot Study of Using Metabolomics to Assess Diet and Metabolic Interventions in Alzheimer’s Disease and Mild Cognitive Impairment
por: Hanson, Angela J., et al.
Publicado: (2023)

Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson’s Disease
por: Hossein-nezhad, Arash, et al.
Publicado: (2016)

Prediction of cognitive progression in Parkinson's disease using three cognitive screening measures
por: Kim, Hojoong M., et al.
Publicado: (2019)

Multivariate prediction of dementia in Parkinson’s disease
por: Phongpreecha, Thanaphong, et al.
Publicado: (2020)

Modular Evolution of the Drosophila Metabolome
por: Harrison, Benjamin R, et al.
Publicado: (2021)

Targeted Discovery and Validation of Plasma Biomarkers of Parkinson’s Disease
por: Pan, Catherine, et al.
Publicado: (2014)

Sensorimotor Inhibition and Mobility in Genetic Subgroups of Parkinson's Disease
por: Martini, Douglas N., et al.
Publicado: (2020)

Quantitative global lipidomics analysis of patients with ovarian cancer versus benign adnexal mass
por: Buas, Matthew F., et al.
Publicado: (2021)

Cognition as a mediator for gait and balance impairments in GBA-related Parkinson’s disease
por: Morris, Rosie, et al.
Publicado: (2022)

Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson’s disease
por: Morris, Rosie, et al.
Publicado: (2023)

DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease
por: Lin, Xiangmin, et al.
Publicado: (2012)

Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease
por: Palmer, William C., et al.
Publicado: (2021)

Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor and Cognitive Function in Non-Demented Subjects
por: Li, Ge, et al.
Publicado: (2009)

Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
por: Li, Ge, et al.
Publicado: (2017)

Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS
por: Blasco, H., et al.
Publicado: (2017)

Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging
por: de Lucia, Claudio, et al.
Publicado: (2020)

The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster
por: Harrison, Benjamin R., et al.
Publicado: (2020)

The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging
por: Staab, Trisha A., et al.
Publicado: (2023)

Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study
por: Fernández-Irigoyen, Joaquín, et al.
Publicado: (2021)

Metabolomic investigations in cerebrospinal fluid of Parkinson's disease
por: Willkommen, Desiree, et al.
Publicado: (2018)

Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype
por: Cooper, Christine A., et al.
Publicado: (2016)

Impact of Blood Collection Tubes and Sample Handling Time on Serum and Plasma Metabolome and Lipidome
por: Cruickshank-Quinn, Charmion, et al.
Publicado: (2018)

Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson’s disease pathogenesis
por: Sheng, Lifu, et al.
Publicado: (2020)

A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid
por: Herskovits, Adrianna Z., et al.
Publicado: (2013)

Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
por: Oliveira, Regina V., et al.
Publicado: (2021)

Preliminary Investigation of the Effect of Maceration Procedures on Bone Metabolome and Lipidome
por: Bonicelli, Andrea, et al.
Publicado: (2022)

Changes in the Cerebrospinal Fluid and Plasma Lipidome in Patients with Rett Syndrome
por: Zandl-Lang, Martina, et al.
Publicado: (2022)

Proteomic, Metabolomic, and Lipidomic Analyses of Lung Tissue Exposed to Mustard Gas
por: Dhummakupt, Elizabeth, et al.
Publicado: (2022)

Integrated Metabolomic and Lipidomic Analysis in the Placenta of Preeclampsia
por: Zhang, Lizi, et al.
Publicado: (2022)

Cerebrospinal fluid lipidomic fingerprint of obstructive sleep apnoea in Alzheimer’s disease
por: Dakterzada, Farida, et al.
Publicado: (2023)

Cerebrospinal Fluid Metabolome in Parkinson’s Disease and Multiple System Atrophy
por: Kwon, Do Hyeon, et al.
Publicado: (2022)

Comparative Metabolomic and Lipidomic Analysis of Phenotype Stratified Prostate Cells
por: Burch, Tanya C., et al.
Publicado: (2015)

Metabolomics and Lipidomics: Yet More Ways Your Health Is Influenced by Fat
por: Yang, Priscilla L.
Publicado: (2016)

A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury
por: Vicente, Elisabeth, et al.
Publicado: (2020)

Metabolomics and Lipidomics Signatures of Insulin Resistance and Abdominal Fat Depots in People Living with Obesity
por: Koay, Yen Chin, et al.
Publicado: (2022)

Inborn Errors of Metabolism in the Era of Untargeted Metabolomics and Lipidomics
por: Ismail, Israa T, et al.
Publicado: (2019)

Plasma metabolomic and lipidomic alterations associated with COVID-19
por: Wu, Di, et al.
Publicado: (2020)

Metabolomics and Lipidomics: Expanding the Molecular Landscape of Exercise Biology
por: Belhaj, Mehdi R., et al.
Publicado: (2021)

KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice
por: Gupta, Shweta, et al.
Publicado: (2022)

Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS)
por: Skill, Nicholas J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3ke7r0jeipruth2vtaha27uovl