Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis

Alzheimer’s disease is the most common type of dementia, reaching 60–80% of case totals, and is one of the major global causes of the elderly population’s decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several others met...

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Autores principales: Athanasaki, Athanasia, Melanis, Konstantinos, Tsantzali, Ioanna, Stefanou, Maria Ioanna, Ntymenou, Sofia, Paraskevas, Sotirios G., Kalamatianos, Theodosis, Boutati, Eleni, Lambadiari, Vaia, Voumvourakis, Konstantinos I., Stranjalis, George, Giannopoulos, Sotirios, Tsivgoulis, Georgios, Paraskevas, George P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029855/
https://www.ncbi.nlm.nih.gov/pubmed/35453527
http://dx.doi.org/10.3390/biomedicines10040778
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author Athanasaki, Athanasia
Melanis, Konstantinos
Tsantzali, Ioanna
Stefanou, Maria Ioanna
Ntymenou, Sofia
Paraskevas, Sotirios G.
Kalamatianos, Theodosis
Boutati, Eleni
Lambadiari, Vaia
Voumvourakis, Konstantinos I.
Stranjalis, George
Giannopoulos, Sotirios
Tsivgoulis, Georgios
Paraskevas, George P.
author_facet Athanasaki, Athanasia
Melanis, Konstantinos
Tsantzali, Ioanna
Stefanou, Maria Ioanna
Ntymenou, Sofia
Paraskevas, Sotirios G.
Kalamatianos, Theodosis
Boutati, Eleni
Lambadiari, Vaia
Voumvourakis, Konstantinos I.
Stranjalis, George
Giannopoulos, Sotirios
Tsivgoulis, Georgios
Paraskevas, George P.
author_sort Athanasaki, Athanasia
collection PubMed
description Alzheimer’s disease is the most common type of dementia, reaching 60–80% of case totals, and is one of the major global causes of the elderly population’s decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several others metabolic factors, diabetes mellitus type 2 is a risk factor of Alzheimer’s disease. Many molecular pathways have been described, and at the same time, there are clues that suggest the connection between type 2 diabetes mellitus and Alzheimer’s disease, through specific genes, autophagy, and even inflammatory pathways. A systematic review with meta-analysis was conducted, and its main goal was to reveal the multilevel connection between these diseases.
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spelling pubmed-90298552022-04-23 Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis Athanasaki, Athanasia Melanis, Konstantinos Tsantzali, Ioanna Stefanou, Maria Ioanna Ntymenou, Sofia Paraskevas, Sotirios G. Kalamatianos, Theodosis Boutati, Eleni Lambadiari, Vaia Voumvourakis, Konstantinos I. Stranjalis, George Giannopoulos, Sotirios Tsivgoulis, Georgios Paraskevas, George P. Biomedicines Systematic Review Alzheimer’s disease is the most common type of dementia, reaching 60–80% of case totals, and is one of the major global causes of the elderly population’s decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several others metabolic factors, diabetes mellitus type 2 is a risk factor of Alzheimer’s disease. Many molecular pathways have been described, and at the same time, there are clues that suggest the connection between type 2 diabetes mellitus and Alzheimer’s disease, through specific genes, autophagy, and even inflammatory pathways. A systematic review with meta-analysis was conducted, and its main goal was to reveal the multilevel connection between these diseases. MDPI 2022-03-27 /pmc/articles/PMC9029855/ /pubmed/35453527 http://dx.doi.org/10.3390/biomedicines10040778 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Athanasaki, Athanasia
Melanis, Konstantinos
Tsantzali, Ioanna
Stefanou, Maria Ioanna
Ntymenou, Sofia
Paraskevas, Sotirios G.
Kalamatianos, Theodosis
Boutati, Eleni
Lambadiari, Vaia
Voumvourakis, Konstantinos I.
Stranjalis, George
Giannopoulos, Sotirios
Tsivgoulis, Georgios
Paraskevas, George P.
Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis
title Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis
title_full Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis
title_fullStr Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis
title_full_unstemmed Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis
title_short Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis
title_sort type 2 diabetes mellitus as a risk factor for alzheimer’s disease: review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029855/
https://www.ncbi.nlm.nih.gov/pubmed/35453527
http://dx.doi.org/10.3390/biomedicines10040778
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