The Role of Inflammasomes in Glomerulonephritis

The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune...

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Autores principales: Anton-Pampols, Paula, Diaz-Requena, Clara, Martinez-Valenzuela, Laura, Gomez-Preciado, Francisco, Fulladosa, Xavier, Vidal-Alabro, Anna, Torras, Joan, Lloberas, Núria, Draibe, Juliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029880/
https://www.ncbi.nlm.nih.gov/pubmed/35457026
http://dx.doi.org/10.3390/ijms23084208
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author Anton-Pampols, Paula
Diaz-Requena, Clara
Martinez-Valenzuela, Laura
Gomez-Preciado, Francisco
Fulladosa, Xavier
Vidal-Alabro, Anna
Torras, Joan
Lloberas, Núria
Draibe, Juliana
author_facet Anton-Pampols, Paula
Diaz-Requena, Clara
Martinez-Valenzuela, Laura
Gomez-Preciado, Francisco
Fulladosa, Xavier
Vidal-Alabro, Anna
Torras, Joan
Lloberas, Núria
Draibe, Juliana
author_sort Anton-Pampols, Paula
collection PubMed
description The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune diseases. It is well known that the kidney expresses inflammasome genes, which can influence the development of some glomerulonephritis, such as lupus nephritis, ANCA glomerulonephritis, IgA nephropathy and anti-GBM nephropathy. Polymorphisms of these genes have also been described to play a role in autoimmune and kidney diseases. In this review, we describe the main characteristics, activation mechanisms, regulation and functions of the different inflammasomes. Moreover, we discuss the latest findings about the role of the inflammasome in several glomerulonephritis from three different points of view: in vitro, animal and human studies.
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spelling pubmed-90298802022-04-23 The Role of Inflammasomes in Glomerulonephritis Anton-Pampols, Paula Diaz-Requena, Clara Martinez-Valenzuela, Laura Gomez-Preciado, Francisco Fulladosa, Xavier Vidal-Alabro, Anna Torras, Joan Lloberas, Núria Draibe, Juliana Int J Mol Sci Review The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune diseases. It is well known that the kidney expresses inflammasome genes, which can influence the development of some glomerulonephritis, such as lupus nephritis, ANCA glomerulonephritis, IgA nephropathy and anti-GBM nephropathy. Polymorphisms of these genes have also been described to play a role in autoimmune and kidney diseases. In this review, we describe the main characteristics, activation mechanisms, regulation and functions of the different inflammasomes. Moreover, we discuss the latest findings about the role of the inflammasome in several glomerulonephritis from three different points of view: in vitro, animal and human studies. MDPI 2022-04-11 /pmc/articles/PMC9029880/ /pubmed/35457026 http://dx.doi.org/10.3390/ijms23084208 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Anton-Pampols, Paula
Diaz-Requena, Clara
Martinez-Valenzuela, Laura
Gomez-Preciado, Francisco
Fulladosa, Xavier
Vidal-Alabro, Anna
Torras, Joan
Lloberas, Núria
Draibe, Juliana
The Role of Inflammasomes in Glomerulonephritis
title The Role of Inflammasomes in Glomerulonephritis
title_full The Role of Inflammasomes in Glomerulonephritis
title_fullStr The Role of Inflammasomes in Glomerulonephritis
title_full_unstemmed The Role of Inflammasomes in Glomerulonephritis
title_short The Role of Inflammasomes in Glomerulonephritis
title_sort role of inflammasomes in glomerulonephritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029880/
https://www.ncbi.nlm.nih.gov/pubmed/35457026
http://dx.doi.org/10.3390/ijms23084208
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