Cargando…
Glucose Increases STAT3 Activation, Promoting Sustained XRCC1 Expression and Increasing DNA Repair
Dysregulation of DNA repair is a hallmark of cancer, though few cancer-specific mechanisms that drive the overexpression of DNA repair proteins are known. We previously identified STAT3 as a novel transcriptional regulator of X-ray cross-complementing group 1 (XRCC1), an essential scaffold protein i...
Autores principales: | Wright, Griffin M., Gassman, Natalie R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029887/ https://www.ncbi.nlm.nih.gov/pubmed/35457130 http://dx.doi.org/10.3390/ijms23084314 |
Ejemplares similares
-
407 Glucose activates STAT3, promoting XRCC1 expression and increased DNA repair after exogenous challenge
por: Gassman, Natalie R, et al.
Publicado: (2022) -
Activated STAT3 Is a Novel Regulator of the XRCC1 Promoter and Selectively Increases XRCC1 Protein Levels in Triple Negative Breast Cancer
por: Wright, Griffin, et al.
Publicado: (2021) -
Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS
por: Kirby, Thomas W., et al.
Publicado: (2015) -
DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients
por: Santos, Raquel A., et al.
Publicado: (2010) -
DNA Repair Genes and Chronic Myeloid Leukemia: ERCC2 (751), XRCC1 (399), XRCC4-Intron 3, XRCC4 (-1394) Gene Polymorphisms
por: Ozdilli, Kursat, et al.
Publicado: (2021)