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Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids

Chronic wasting disease (CWD) is a prion disease that affects cervids; it is classified under transmissible spongiform encephalopathies (TSEs). CWD is particularly contagious, making its eradication in endemic areas very difficult and creating serious problems for cervid conservation and breeding. I...

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Autores principales: Tripodi, Letizia, Ru, Giuseppe, Lazzara, Fabrizio, Florio, Lucia Caterina, Cocco, Cinzia, Meloni, Daniela, Maria, Mazza, Bozzetta, Elena, Perrotta, Maria Gabriella, Caramelli, Maria, Casalone, Cristina, Iulini, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029944/
https://www.ncbi.nlm.nih.gov/pubmed/35456076
http://dx.doi.org/10.3390/pathogens11040401
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author Tripodi, Letizia
Ru, Giuseppe
Lazzara, Fabrizio
Florio, Lucia Caterina
Cocco, Cinzia
Meloni, Daniela
Maria, Mazza
Bozzetta, Elena
Perrotta, Maria Gabriella
Caramelli, Maria
Casalone, Cristina
Iulini, Barbara
author_facet Tripodi, Letizia
Ru, Giuseppe
Lazzara, Fabrizio
Florio, Lucia Caterina
Cocco, Cinzia
Meloni, Daniela
Maria, Mazza
Bozzetta, Elena
Perrotta, Maria Gabriella
Caramelli, Maria
Casalone, Cristina
Iulini, Barbara
author_sort Tripodi, Letizia
collection PubMed
description Chronic wasting disease (CWD) is a prion disease that affects cervids; it is classified under transmissible spongiform encephalopathies (TSEs). CWD is particularly contagious, making its eradication in endemic areas very difficult and creating serious problems for cervid conservation and breeding. It has recently become an emerging public health risk to be managed by health authorities. Starting in 2017, active CWD surveillance in Italy has intensified with the monitoring of wild and farmed cervids. The present study summarizes findings from a histopathological survey of the brains from wild ruminants collected via CWD monitoring between 2017 and 2019. A total of 113 brains from 62 red deer (Cervus elaphus) and 51 roe deer (Capreolus capreolus) were submitted for analysis at the National Reference Center for Animal Encephalopathies (CEA) to determine major patterns of neuropathological lesions and correlated pathogens. Brain lesions were detected in 20 animals, 10 brain samples were unsuitable for examination, and 83 presented no lesions. Neuropathological examination revealed non-suppurative encephalitis or meningoencephalitis in most cases (15/20). This brain study revealed evidence for the absence of CWD in Italy and provided a reference spectrum of neuropathological lesions for differential diagnosis in cervids.
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spelling pubmed-90299442022-04-23 Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids Tripodi, Letizia Ru, Giuseppe Lazzara, Fabrizio Florio, Lucia Caterina Cocco, Cinzia Meloni, Daniela Maria, Mazza Bozzetta, Elena Perrotta, Maria Gabriella Caramelli, Maria Casalone, Cristina Iulini, Barbara Pathogens Communication Chronic wasting disease (CWD) is a prion disease that affects cervids; it is classified under transmissible spongiform encephalopathies (TSEs). CWD is particularly contagious, making its eradication in endemic areas very difficult and creating serious problems for cervid conservation and breeding. It has recently become an emerging public health risk to be managed by health authorities. Starting in 2017, active CWD surveillance in Italy has intensified with the monitoring of wild and farmed cervids. The present study summarizes findings from a histopathological survey of the brains from wild ruminants collected via CWD monitoring between 2017 and 2019. A total of 113 brains from 62 red deer (Cervus elaphus) and 51 roe deer (Capreolus capreolus) were submitted for analysis at the National Reference Center for Animal Encephalopathies (CEA) to determine major patterns of neuropathological lesions and correlated pathogens. Brain lesions were detected in 20 animals, 10 brain samples were unsuitable for examination, and 83 presented no lesions. Neuropathological examination revealed non-suppurative encephalitis or meningoencephalitis in most cases (15/20). This brain study revealed evidence for the absence of CWD in Italy and provided a reference spectrum of neuropathological lesions for differential diagnosis in cervids. MDPI 2022-03-26 /pmc/articles/PMC9029944/ /pubmed/35456076 http://dx.doi.org/10.3390/pathogens11040401 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Tripodi, Letizia
Ru, Giuseppe
Lazzara, Fabrizio
Florio, Lucia Caterina
Cocco, Cinzia
Meloni, Daniela
Maria, Mazza
Bozzetta, Elena
Perrotta, Maria Gabriella
Caramelli, Maria
Casalone, Cristina
Iulini, Barbara
Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids
title Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids
title_full Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids
title_fullStr Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids
title_full_unstemmed Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids
title_short Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids
title_sort chronic wasting disease monitoring in italy 2017–2019: neuropathological findings in cervids
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029944/
https://www.ncbi.nlm.nih.gov/pubmed/35456076
http://dx.doi.org/10.3390/pathogens11040401
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