BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review

Breast cancer in trans women is rare. Only 21 cases have been reported worldwide. Multidisciplinary teams must balance oncologic treatment with patient goals. Here we describe a case of invasive ductal carcinoma in a transgender woman who was found to have a BRCA2 gene mutation. A shared decision-ma...

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Detalles Bibliográficos
Autores principales: Cole, Naomi A., Copeland-Halperin, Libby R., Shank, Nina, Shankaran, Vidya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Gender-Affirming Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029988/
https://www.ncbi.nlm.nih.gov/pubmed/35475284
http://dx.doi.org/10.1097/GOX.0000000000004059
Descripción
Sumario:Breast cancer in trans women is rare. Only 21 cases have been reported worldwide. Multidisciplinary teams must balance oncologic treatment with patient goals. Here we describe a case of invasive ductal carcinoma in a transgender woman who was found to have a BRCA2 gene mutation. A shared decision-making process led to the patient undergoing bilateral nipple-sparing mastectomy with immediate tissue expander placement. Later findings prompted discussions about adjuvant chemotherapy and radiation. Additionally, we discuss the complexities associated with reconstructing a transfeminine chest.

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