BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review

Breast cancer in trans women is rare. Only 21 cases have been reported worldwide. Multidisciplinary teams must balance oncologic treatment with patient goals. Here we describe a case of invasive ductal carcinoma in a transgender woman who was found to have a BRCA2 gene mutation. A shared decision-ma...

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Detalles Bibliográficos
Autores principales: Cole, Naomi A., Copeland-Halperin, Libby R., Shank, Nina, Shankaran, Vidya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Gender-Affirming Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029988/
https://www.ncbi.nlm.nih.gov/pubmed/35475284
http://dx.doi.org/10.1097/GOX.0000000000004059
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author Cole, Naomi A.
Copeland-Halperin, Libby R.
Shank, Nina
Shankaran, Vidya
author_facet Cole, Naomi A.
Copeland-Halperin, Libby R.
Shank, Nina
Shankaran, Vidya
author_sort Cole, Naomi A.
collection PubMed
description Breast cancer in trans women is rare. Only 21 cases have been reported worldwide. Multidisciplinary teams must balance oncologic treatment with patient goals. Here we describe a case of invasive ductal carcinoma in a transgender woman who was found to have a BRCA2 gene mutation. A shared decision-making process led to the patient undergoing bilateral nipple-sparing mastectomy with immediate tissue expander placement. Later findings prompted discussions about adjuvant chemotherapy and radiation. Additionally, we discuss the complexities associated with reconstructing a transfeminine chest.
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spelling pubmed-90299882022-04-25 BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review Cole, Naomi A. Copeland-Halperin, Libby R. Shank, Nina Shankaran, Vidya Plast Reconstr Surg Glob Open Gender-Affirming Surgery Breast cancer in trans women is rare. Only 21 cases have been reported worldwide. Multidisciplinary teams must balance oncologic treatment with patient goals. Here we describe a case of invasive ductal carcinoma in a transgender woman who was found to have a BRCA2 gene mutation. A shared decision-making process led to the patient undergoing bilateral nipple-sparing mastectomy with immediate tissue expander placement. Later findings prompted discussions about adjuvant chemotherapy and radiation. Additionally, we discuss the complexities associated with reconstructing a transfeminine chest. Lippincott Williams & Wilkins 2022-04-22 /pmc/articles/PMC9029988/ /pubmed/35475284 http://dx.doi.org/10.1097/GOX.0000000000004059 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Gender-Affirming Surgery
Cole, Naomi A.
Copeland-Halperin, Libby R.
Shank, Nina
Shankaran, Vidya
BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review
title BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review
title_full BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review
title_fullStr BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review
title_full_unstemmed BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review
title_short BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review
title_sort brca2-associated breast cancer in transgender women: reconstructive challenges and literature review
topic Gender-Affirming Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029988/
https://www.ncbi.nlm.nih.gov/pubmed/35475284
http://dx.doi.org/10.1097/GOX.0000000000004059
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