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Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma
A retrospective chart survey of the clinical features of indolent adult T-cell leukemia/lymphoma (ATL) was conducted in the Miyazaki Prefecture, Japan. This study enrolled 24 smoldering-type ATLs, 10 favorable chronic-type ATLs, and 20 unfavorable chronic-type ATLs diagnosed between 2010 and 2018. A...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030133/ https://www.ncbi.nlm.nih.gov/pubmed/35458440 http://dx.doi.org/10.3390/v14040710 |
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author | Kameda, Takuro Shide, Kotaro Tahira, Yuki Sekine, Masaaki Sato, Seiichi Ishizaki, Junzo Takeuchi, Masanori Akizuki, Keiichi Kamiunten, Ayako Shimoda, Haruko Toyama, Takanori Maeda, Kouichi Yamashita, Kiyoshi Kawano, Noriaki Kawano, Hiroshi Hidaka, Tomonori Yamaguchi, Hideki Kubuki, Yoko Kitanaka, Akira Matsuoka, Hitoshi Shimoda, Kazuya |
author_facet | Kameda, Takuro Shide, Kotaro Tahira, Yuki Sekine, Masaaki Sato, Seiichi Ishizaki, Junzo Takeuchi, Masanori Akizuki, Keiichi Kamiunten, Ayako Shimoda, Haruko Toyama, Takanori Maeda, Kouichi Yamashita, Kiyoshi Kawano, Noriaki Kawano, Hiroshi Hidaka, Tomonori Yamaguchi, Hideki Kubuki, Yoko Kitanaka, Akira Matsuoka, Hitoshi Shimoda, Kazuya |
author_sort | Kameda, Takuro |
collection | PubMed |
description | A retrospective chart survey of the clinical features of indolent adult T-cell leukemia/lymphoma (ATL) was conducted in the Miyazaki Prefecture, Japan. This study enrolled 24 smoldering-type ATLs, 10 favorable chronic-type ATLs, and 20 unfavorable chronic-type ATLs diagnosed between 2010 and 2018. Among them, 4, 3, and 10 progressed to acute-type ATLs during their clinical course. The median survival time (MST) in smoldering-type ATL and favorable chronic-type ATL was not reached, and their 4-year overall survival (OS) was 73% and 79%, respectively. Compared with this, the prognosis of unfavorable chronic-type ATL was poor. Its MST was 3.32 years, and the 4-year OS was 46% (p = 0.0095). In addition to the three features that determine the unfavorable characteristics of chronic-type ATL, namely, increased lactate dehydrogenase, increased blood urea nitrogen, and decreased albumin, the high-risk category by the indolent ATL-Prognostic Index, which was defined by an increment of soluble interleukin-2 receptor (sIL2-R) of >6000 U/mL, could explain the poor prognosis in indolent ATL patients. The level of sIL-2R might be an indicator of the initiation of therapy for indolent ATL. |
format | Online Article Text |
id | pubmed-9030133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90301332022-04-23 Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma Kameda, Takuro Shide, Kotaro Tahira, Yuki Sekine, Masaaki Sato, Seiichi Ishizaki, Junzo Takeuchi, Masanori Akizuki, Keiichi Kamiunten, Ayako Shimoda, Haruko Toyama, Takanori Maeda, Kouichi Yamashita, Kiyoshi Kawano, Noriaki Kawano, Hiroshi Hidaka, Tomonori Yamaguchi, Hideki Kubuki, Yoko Kitanaka, Akira Matsuoka, Hitoshi Shimoda, Kazuya Viruses Article A retrospective chart survey of the clinical features of indolent adult T-cell leukemia/lymphoma (ATL) was conducted in the Miyazaki Prefecture, Japan. This study enrolled 24 smoldering-type ATLs, 10 favorable chronic-type ATLs, and 20 unfavorable chronic-type ATLs diagnosed between 2010 and 2018. Among them, 4, 3, and 10 progressed to acute-type ATLs during their clinical course. The median survival time (MST) in smoldering-type ATL and favorable chronic-type ATL was not reached, and their 4-year overall survival (OS) was 73% and 79%, respectively. Compared with this, the prognosis of unfavorable chronic-type ATL was poor. Its MST was 3.32 years, and the 4-year OS was 46% (p = 0.0095). In addition to the three features that determine the unfavorable characteristics of chronic-type ATL, namely, increased lactate dehydrogenase, increased blood urea nitrogen, and decreased albumin, the high-risk category by the indolent ATL-Prognostic Index, which was defined by an increment of soluble interleukin-2 receptor (sIL2-R) of >6000 U/mL, could explain the poor prognosis in indolent ATL patients. The level of sIL-2R might be an indicator of the initiation of therapy for indolent ATL. MDPI 2022-03-29 /pmc/articles/PMC9030133/ /pubmed/35458440 http://dx.doi.org/10.3390/v14040710 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kameda, Takuro Shide, Kotaro Tahira, Yuki Sekine, Masaaki Sato, Seiichi Ishizaki, Junzo Takeuchi, Masanori Akizuki, Keiichi Kamiunten, Ayako Shimoda, Haruko Toyama, Takanori Maeda, Kouichi Yamashita, Kiyoshi Kawano, Noriaki Kawano, Hiroshi Hidaka, Tomonori Yamaguchi, Hideki Kubuki, Yoko Kitanaka, Akira Matsuoka, Hitoshi Shimoda, Kazuya Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma |
title | Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma |
title_full | Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma |
title_fullStr | Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma |
title_full_unstemmed | Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma |
title_short | Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma |
title_sort | prognosis of indolent adult t-cell leukemia/lymphoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030133/ https://www.ncbi.nlm.nih.gov/pubmed/35458440 http://dx.doi.org/10.3390/v14040710 |
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