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Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study

Increasing data suggest that overnutrition-induced obesity may trigger an inflammatory process in adipose tissue and upturn in the innate immune system. Numerous players have been involved in governing the inflammatory response, including epigenetics. Among epigenetic players, miRNAs are emerging as...

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Autores principales: Lauria, Fabio, Iacomino, Giuseppe, Russo, Paola, Venezia, Antonella, Marena, Pasquale, Ahrens, Wolfgang, De Henauw, Stefaan, Eiben, Gabriele, Foraita, Ronja, Hebestreit, Antje, Kourides, Yiannis, Molnár, Dénes, Moreno, Luis A., Veidebaum, Toomas, Siani, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030192/
https://www.ncbi.nlm.nih.gov/pubmed/35456438
http://dx.doi.org/10.3390/genes13040632
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author Lauria, Fabio
Iacomino, Giuseppe
Russo, Paola
Venezia, Antonella
Marena, Pasquale
Ahrens, Wolfgang
De Henauw, Stefaan
Eiben, Gabriele
Foraita, Ronja
Hebestreit, Antje
Kourides, Yiannis
Molnár, Dénes
Moreno, Luis A.
Veidebaum, Toomas
Siani, Alfonso
author_facet Lauria, Fabio
Iacomino, Giuseppe
Russo, Paola
Venezia, Antonella
Marena, Pasquale
Ahrens, Wolfgang
De Henauw, Stefaan
Eiben, Gabriele
Foraita, Ronja
Hebestreit, Antje
Kourides, Yiannis
Molnár, Dénes
Moreno, Luis A.
Veidebaum, Toomas
Siani, Alfonso
author_sort Lauria, Fabio
collection PubMed
description Increasing data suggest that overnutrition-induced obesity may trigger an inflammatory process in adipose tissue and upturn in the innate immune system. Numerous players have been involved in governing the inflammatory response, including epigenetics. Among epigenetic players, miRNAs are emerging as crucial regulators of immune cell development, immune responses, autoimmunity, and inflammation. In this study, we aimed at identifying the involvement of candidate miRNAs in relation to inflammation-associated biomarkers in a subsample of European children with overweight and obesity participating in the I.Family study. The study sample included individuals with increased adiposity since this condition contributes to the early occurrence of chronic low-grade inflammation. We focused on the acute-phase reagent C-reactive protein (CRP) as the primary outcome and selected cytokines as plausible biomarkers of inflammation. We found that chronic low-grade CRP elevation shows a highly significant association with miR-26b-3p and hsa-miR-576-5p in boys. Furthermore, the association of CRP with hsa-miR-10b-5p and hsa-miR-31-5p is highly significant in girls. We also observed major sex-related associations of candidate miRNAs with selected cytokines. Except for IL-6, a significant association of hsa-miR-26b-3p and hsa-miR-576-5p with TNF-α, IL1-Ra, IL-8, and IL-15 levels was found exclusively in boys. The findings of this exploratory study suggest sex differences in the association of circulating miRNAs with inflammatory response biomarkers, and indicate a possible role of miRNAs among the candidate epigenetic mechanisms related to the process of low-grade inflammation in childhood obesity.
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spelling pubmed-90301922022-04-23 Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study Lauria, Fabio Iacomino, Giuseppe Russo, Paola Venezia, Antonella Marena, Pasquale Ahrens, Wolfgang De Henauw, Stefaan Eiben, Gabriele Foraita, Ronja Hebestreit, Antje Kourides, Yiannis Molnár, Dénes Moreno, Luis A. Veidebaum, Toomas Siani, Alfonso Genes (Basel) Article Increasing data suggest that overnutrition-induced obesity may trigger an inflammatory process in adipose tissue and upturn in the innate immune system. Numerous players have been involved in governing the inflammatory response, including epigenetics. Among epigenetic players, miRNAs are emerging as crucial regulators of immune cell development, immune responses, autoimmunity, and inflammation. In this study, we aimed at identifying the involvement of candidate miRNAs in relation to inflammation-associated biomarkers in a subsample of European children with overweight and obesity participating in the I.Family study. The study sample included individuals with increased adiposity since this condition contributes to the early occurrence of chronic low-grade inflammation. We focused on the acute-phase reagent C-reactive protein (CRP) as the primary outcome and selected cytokines as plausible biomarkers of inflammation. We found that chronic low-grade CRP elevation shows a highly significant association with miR-26b-3p and hsa-miR-576-5p in boys. Furthermore, the association of CRP with hsa-miR-10b-5p and hsa-miR-31-5p is highly significant in girls. We also observed major sex-related associations of candidate miRNAs with selected cytokines. Except for IL-6, a significant association of hsa-miR-26b-3p and hsa-miR-576-5p with TNF-α, IL1-Ra, IL-8, and IL-15 levels was found exclusively in boys. The findings of this exploratory study suggest sex differences in the association of circulating miRNAs with inflammatory response biomarkers, and indicate a possible role of miRNAs among the candidate epigenetic mechanisms related to the process of low-grade inflammation in childhood obesity. MDPI 2022-04-01 /pmc/articles/PMC9030192/ /pubmed/35456438 http://dx.doi.org/10.3390/genes13040632 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lauria, Fabio
Iacomino, Giuseppe
Russo, Paola
Venezia, Antonella
Marena, Pasquale
Ahrens, Wolfgang
De Henauw, Stefaan
Eiben, Gabriele
Foraita, Ronja
Hebestreit, Antje
Kourides, Yiannis
Molnár, Dénes
Moreno, Luis A.
Veidebaum, Toomas
Siani, Alfonso
Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study
title Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study
title_full Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study
title_fullStr Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study
title_full_unstemmed Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study
title_short Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study
title_sort circulating mirnas are associated with inflammation biomarkers in children with overweight and obesity: results of the i.family study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030192/
https://www.ncbi.nlm.nih.gov/pubmed/35456438
http://dx.doi.org/10.3390/genes13040632
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