Association of Androgenic Regulation and MicroRNAs in Acinar Adenocarcinoma of Prostate

Background: Prostate cancer represents 3.8% of cancer deaths worldwide. For most prostate cancer cells to grow, androgens need to bind to a cellular protein called the androgen receptor (AR). This study aims to demonstrate the expression of five microRNAs (miRs) and its influence on the AR formation...

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Detalles Bibliográficos
Autores principales: Bernardes, Julio Guilherme Balieiro, Fernandes, Marianne Rodrigues, Rodrigues, Juliana Carla Gomes, Vinagre, Lui Wallacy Morikawa Souza, Pastana, Lucas Favacho, Dobbin, Elizabeth Ayres Fragoso, Medeiros, Jéssyca Amanda Gomes, Dias Junior, Leonidas Braga, Bernardes, Gabriel Monteiro, Bernardes, Izabel Maria Monteiro, Santos, Ney Pereira Carneiro Dos, Demachki, Samia, Burbano, Rommel Mario Rodriguez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030213/
https://www.ncbi.nlm.nih.gov/pubmed/35456428
http://dx.doi.org/10.3390/genes13040622
Descripción
Sumario:Background: Prostate cancer represents 3.8% of cancer deaths worldwide. For most prostate cancer cells to grow, androgens need to bind to a cellular protein called the androgen receptor (AR). This study aims to demonstrate the expression of five microRNAs (miRs) and its influence on the AR formation in patients from the northern region of Brazil. Material and Methods: Eighty-four tissue samples were investigated, including nodular prostatic hyperplasia (NPH) and acinar prostatic adenocarcinoma (CaP). Five miRs (27a-3p, 124, 130a, 488-3p, and 506) were quantified using the TaqMan(®) Real Time PCR method and AR was measured using Western blotting. Results: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples. Conversely, in the CaP cases, higher levels of miR 27a-3p and AR were observed. Conclusion: In the future, these microRNAs may be tested as markers of CaP at the serum level. The relative expression of AR was 20% higher in patients with prostate cancer, which suggests its potential as a biomarker for prostate malignancy.

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