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Lactational Changes of Phospholipids Content and Composition in Chinese Breast Milk

Phospholipids are pivotal polar lipids in human milk and essential for infants’ growth and development, especially in the brain and cognitive development. Its content and composition are affected by multiple factors and there exist discrepancies in different studies. In this study, we determined fiv...

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Autores principales: Yang, Meng-Tao, Lan, Qiu-Ye, Liang, Xue, Mao, Ying-Yi, Cai, Xiao-Kun, Tian, Fang, Liu, Zhao-Yan, Li, Xiang, Zhao, Yan-Rong, Zhu, Hui-Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030290/
https://www.ncbi.nlm.nih.gov/pubmed/35458100
http://dx.doi.org/10.3390/nu14081539
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author Yang, Meng-Tao
Lan, Qiu-Ye
Liang, Xue
Mao, Ying-Yi
Cai, Xiao-Kun
Tian, Fang
Liu, Zhao-Yan
Li, Xiang
Zhao, Yan-Rong
Zhu, Hui-Lian
author_facet Yang, Meng-Tao
Lan, Qiu-Ye
Liang, Xue
Mao, Ying-Yi
Cai, Xiao-Kun
Tian, Fang
Liu, Zhao-Yan
Li, Xiang
Zhao, Yan-Rong
Zhu, Hui-Lian
author_sort Yang, Meng-Tao
collection PubMed
description Phospholipids are pivotal polar lipids in human milk and essential for infants’ growth and development, especially in the brain and cognitive development. Its content and composition are affected by multiple factors and there exist discrepancies in different studies. In this study, we determined five major phospholipids classes (phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylcholine, and sphingomyelin) in 2270 human milk samples collected from 0 to 400 days postpartum in six regions of China. The high-performance liquid chromatography coupled with an evaporative light scattering detector (HPLC-ELSD) was performed to quantify the phospholipids. Total phospholipid median (IQR) content was in a range between 170.38 ± 96.52 mg/L to 195.69 ± 81.80 mg/L during lactation and was higher concentrated in colostrum milk and later stage of lactation (after 200 days postpartum) compared with that in the samples collected between 10 to 45 days postpartum. Variations in five major sub-class phospholipids content were also observed across lactation stages (phosphatidylethanolamine: 52.61 ± 29.05 to 59.95 ± 41.74 mg/L; phosphatidylinositol: 17.65 ± 10.68 to 20.38 ± 8.55 mg/L; phosphatidylserine: 15.98 ± 9.02 to 22.77 ± 11.17 mg/L; phosphatidylcholine: 34.13 ± 25.33 to 48.64 ± 19.73 mg/L; sphingomyelin: 41.35 ± 20.31 to 54.79 ± 35.26 mg/L). Phosphatidylethanolamine (29.18–32.52%), phosphatidylcholine (19.90–25.04%) and sphingomyelin (22.39–29.17%) were the dominant sub-class phospholipids in Chinese breast milk during the whole lactation period. These results updated phospholipids data in Chinese human milk and could provide evidence for better development of secure and effective human milk surrogates for infants without access to breast milk.
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spelling pubmed-90302902022-04-23 Lactational Changes of Phospholipids Content and Composition in Chinese Breast Milk Yang, Meng-Tao Lan, Qiu-Ye Liang, Xue Mao, Ying-Yi Cai, Xiao-Kun Tian, Fang Liu, Zhao-Yan Li, Xiang Zhao, Yan-Rong Zhu, Hui-Lian Nutrients Article Phospholipids are pivotal polar lipids in human milk and essential for infants’ growth and development, especially in the brain and cognitive development. Its content and composition are affected by multiple factors and there exist discrepancies in different studies. In this study, we determined five major phospholipids classes (phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylcholine, and sphingomyelin) in 2270 human milk samples collected from 0 to 400 days postpartum in six regions of China. The high-performance liquid chromatography coupled with an evaporative light scattering detector (HPLC-ELSD) was performed to quantify the phospholipids. Total phospholipid median (IQR) content was in a range between 170.38 ± 96.52 mg/L to 195.69 ± 81.80 mg/L during lactation and was higher concentrated in colostrum milk and later stage of lactation (after 200 days postpartum) compared with that in the samples collected between 10 to 45 days postpartum. Variations in five major sub-class phospholipids content were also observed across lactation stages (phosphatidylethanolamine: 52.61 ± 29.05 to 59.95 ± 41.74 mg/L; phosphatidylinositol: 17.65 ± 10.68 to 20.38 ± 8.55 mg/L; phosphatidylserine: 15.98 ± 9.02 to 22.77 ± 11.17 mg/L; phosphatidylcholine: 34.13 ± 25.33 to 48.64 ± 19.73 mg/L; sphingomyelin: 41.35 ± 20.31 to 54.79 ± 35.26 mg/L). Phosphatidylethanolamine (29.18–32.52%), phosphatidylcholine (19.90–25.04%) and sphingomyelin (22.39–29.17%) were the dominant sub-class phospholipids in Chinese breast milk during the whole lactation period. These results updated phospholipids data in Chinese human milk and could provide evidence for better development of secure and effective human milk surrogates for infants without access to breast milk. MDPI 2022-04-07 /pmc/articles/PMC9030290/ /pubmed/35458100 http://dx.doi.org/10.3390/nu14081539 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Meng-Tao
Lan, Qiu-Ye
Liang, Xue
Mao, Ying-Yi
Cai, Xiao-Kun
Tian, Fang
Liu, Zhao-Yan
Li, Xiang
Zhao, Yan-Rong
Zhu, Hui-Lian
Lactational Changes of Phospholipids Content and Composition in Chinese Breast Milk
title Lactational Changes of Phospholipids Content and Composition in Chinese Breast Milk
title_full Lactational Changes of Phospholipids Content and Composition in Chinese Breast Milk
title_fullStr Lactational Changes of Phospholipids Content and Composition in Chinese Breast Milk
title_full_unstemmed Lactational Changes of Phospholipids Content and Composition in Chinese Breast Milk
title_short Lactational Changes of Phospholipids Content and Composition in Chinese Breast Milk
title_sort lactational changes of phospholipids content and composition in chinese breast milk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030290/
https://www.ncbi.nlm.nih.gov/pubmed/35458100
http://dx.doi.org/10.3390/nu14081539
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