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High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York
A residential building’s wastewater presents a potential non-invasive method of surveilling numerous infectious diseases, including SARS-CoV-2. We analyzed wastewater from 16 different residential locations at Syracuse University (Syracuse, NY, USA) during fall semester 2020, testing for SARS-CoV-2...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030442/ https://www.ncbi.nlm.nih.gov/pubmed/35457720 http://dx.doi.org/10.3390/ijerph19084851 |
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author | Godinez, Alex Hill, Dustin Dandaraw, Bryan Green, Hyatt Kilaru, Pruthvi Middleton, Frank Run, Sythong Kmush, Brittany L. Larsen, David A. |
author_facet | Godinez, Alex Hill, Dustin Dandaraw, Bryan Green, Hyatt Kilaru, Pruthvi Middleton, Frank Run, Sythong Kmush, Brittany L. Larsen, David A. |
author_sort | Godinez, Alex |
collection | PubMed |
description | A residential building’s wastewater presents a potential non-invasive method of surveilling numerous infectious diseases, including SARS-CoV-2. We analyzed wastewater from 16 different residential locations at Syracuse University (Syracuse, NY, USA) during fall semester 2020, testing for SARS-CoV-2 RNA twice weekly and compared the presence of clinical COVID-19 cases to detection of the viral RNA in wastewater. The sensitivity of wastewater surveillance to correctly identify dormitories with a case of COVID-19 ranged from 95% (95% confidence interval [CI] = 76–100%) on the same day as the case was diagnosed to 73% (95% CI = 53–92%), with 7 days lead time of wastewater. The positive predictive value ranged from 20% (95% CI = 13–30%) on the same day as the case was diagnosed to 50% (95% CI = 40–60%) with 7 days lead time. The specificity of wastewater surveillance to correctly identify dormitories without a case of COVID-19 ranged from 60% (95% CI = 52–67%) on the day of the wastewater sample to 67% (95% CI = 58–74%) with 7 days lead time. The negative predictive value ranged from 99% (95% CI = 95–100%) on the day of the wastewater sample to 84% (95% CI = 77–91%) with 7 days lead time. Wastewater surveillance for SARS-CoV-2 at the building level is highly accurate in determining if residents have a COVID-19 infection. Particular benefit is derived from negative wastewater results that can confirm a building is COVID-19 free. |
format | Online Article Text |
id | pubmed-9030442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90304422022-04-23 High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York Godinez, Alex Hill, Dustin Dandaraw, Bryan Green, Hyatt Kilaru, Pruthvi Middleton, Frank Run, Sythong Kmush, Brittany L. Larsen, David A. Int J Environ Res Public Health Article A residential building’s wastewater presents a potential non-invasive method of surveilling numerous infectious diseases, including SARS-CoV-2. We analyzed wastewater from 16 different residential locations at Syracuse University (Syracuse, NY, USA) during fall semester 2020, testing for SARS-CoV-2 RNA twice weekly and compared the presence of clinical COVID-19 cases to detection of the viral RNA in wastewater. The sensitivity of wastewater surveillance to correctly identify dormitories with a case of COVID-19 ranged from 95% (95% confidence interval [CI] = 76–100%) on the same day as the case was diagnosed to 73% (95% CI = 53–92%), with 7 days lead time of wastewater. The positive predictive value ranged from 20% (95% CI = 13–30%) on the same day as the case was diagnosed to 50% (95% CI = 40–60%) with 7 days lead time. The specificity of wastewater surveillance to correctly identify dormitories without a case of COVID-19 ranged from 60% (95% CI = 52–67%) on the day of the wastewater sample to 67% (95% CI = 58–74%) with 7 days lead time. The negative predictive value ranged from 99% (95% CI = 95–100%) on the day of the wastewater sample to 84% (95% CI = 77–91%) with 7 days lead time. Wastewater surveillance for SARS-CoV-2 at the building level is highly accurate in determining if residents have a COVID-19 infection. Particular benefit is derived from negative wastewater results that can confirm a building is COVID-19 free. MDPI 2022-04-16 /pmc/articles/PMC9030442/ /pubmed/35457720 http://dx.doi.org/10.3390/ijerph19084851 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Godinez, Alex Hill, Dustin Dandaraw, Bryan Green, Hyatt Kilaru, Pruthvi Middleton, Frank Run, Sythong Kmush, Brittany L. Larsen, David A. High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York |
title | High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York |
title_full | High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York |
title_fullStr | High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York |
title_full_unstemmed | High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York |
title_short | High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York |
title_sort | high sensitivity and specificity of dormitory-level wastewater surveillance for covid-19 during fall semester 2020 at syracuse university, new york |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030442/ https://www.ncbi.nlm.nih.gov/pubmed/35457720 http://dx.doi.org/10.3390/ijerph19084851 |
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