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Practical one-pot amidation of N-Alloc-, N-Boc-, and N-Cbz protected amines under mild conditions
A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagent...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030462/ https://www.ncbi.nlm.nih.gov/pubmed/35481162 http://dx.doi.org/10.1039/d1ra02242c |