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The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients

SIMPLE SUMMARY: Radiation therapy is highly effective and well tolerated in the treatment of localized Kaposi’s sarcoma. In this work, we reviewed the literature to evaluate the efficacy and side effects of radiotherapy in Kaposi’s sarcoma before and after the initiation of highly active antiretrovi...

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Autores principales: Quéro, Laurent, Palich, Romain, Valantin, Marc-Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030503/
https://www.ncbi.nlm.nih.gov/pubmed/35454820
http://dx.doi.org/10.3390/cancers14081915
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author Quéro, Laurent
Palich, Romain
Valantin, Marc-Antoine
author_facet Quéro, Laurent
Palich, Romain
Valantin, Marc-Antoine
author_sort Quéro, Laurent
collection PubMed
description SIMPLE SUMMARY: Radiation therapy is highly effective and well tolerated in the treatment of localized Kaposi’s sarcoma. In this work, we reviewed the literature to evaluate the efficacy and side effects of radiotherapy in Kaposi’s sarcoma before and after the initiation of highly active antiretroviral therapy and described the indications and modalities of radiotherapy treatment. ABSTRACT: Kaposi’s sarcoma (KS) is a radiosensitive cancer regardless of its form (classical, endemic, AIDS-related, and immunosuppressant therapy-related). Radiotherapy (RT) is an integral part of the therapeutic management of KS. RT may be used as the main treatment, in the case of solitary lesions, or as palliative therapy in the disseminated forms. The dose of RT to be delivered is 20–30 Gy by low-energy photons or by electrons. The complete response rate after RT is high, around 80–90%. This treatment is well tolerated. However, patients should be informed of the possible risk of the development of late skin sequelae and the possibility of recurrence. With the advent of highly active antiretroviral therapy (HAART), the indications for RT treatment in HIV-positive patients have decreased.
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spelling pubmed-90305032022-04-23 The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients Quéro, Laurent Palich, Romain Valantin, Marc-Antoine Cancers (Basel) Review SIMPLE SUMMARY: Radiation therapy is highly effective and well tolerated in the treatment of localized Kaposi’s sarcoma. In this work, we reviewed the literature to evaluate the efficacy and side effects of radiotherapy in Kaposi’s sarcoma before and after the initiation of highly active antiretroviral therapy and described the indications and modalities of radiotherapy treatment. ABSTRACT: Kaposi’s sarcoma (KS) is a radiosensitive cancer regardless of its form (classical, endemic, AIDS-related, and immunosuppressant therapy-related). Radiotherapy (RT) is an integral part of the therapeutic management of KS. RT may be used as the main treatment, in the case of solitary lesions, or as palliative therapy in the disseminated forms. The dose of RT to be delivered is 20–30 Gy by low-energy photons or by electrons. The complete response rate after RT is high, around 80–90%. This treatment is well tolerated. However, patients should be informed of the possible risk of the development of late skin sequelae and the possibility of recurrence. With the advent of highly active antiretroviral therapy (HAART), the indications for RT treatment in HIV-positive patients have decreased. MDPI 2022-04-10 /pmc/articles/PMC9030503/ /pubmed/35454820 http://dx.doi.org/10.3390/cancers14081915 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Quéro, Laurent
Palich, Romain
Valantin, Marc-Antoine
The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients
title The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients
title_full The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients
title_fullStr The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients
title_full_unstemmed The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients
title_short The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients
title_sort role of radiotherapy in treating kaposi’s sarcoma in hiv infected patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030503/
https://www.ncbi.nlm.nih.gov/pubmed/35454820
http://dx.doi.org/10.3390/cancers14081915
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