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Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility

Biochemical markers of spermatogenesis and fertility assessment are important in the practical management of infertile males and the determination of an individual’s prognosis. We performed an analysis on 100 males with a male infertility factor. The following study inclusion parameters were analyze...

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Autores principales: Jankowska, Katarzyna, Suszczewicz, Natalia, Rabijewski, Michał, Dudek, Piotr, Zgliczyński, Wojciech, Maksym, Radosław B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030543/
https://www.ncbi.nlm.nih.gov/pubmed/35455002
http://dx.doi.org/10.3390/life12040511
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author Jankowska, Katarzyna
Suszczewicz, Natalia
Rabijewski, Michał
Dudek, Piotr
Zgliczyński, Wojciech
Maksym, Radosław B.
author_facet Jankowska, Katarzyna
Suszczewicz, Natalia
Rabijewski, Michał
Dudek, Piotr
Zgliczyński, Wojciech
Maksym, Radosław B.
author_sort Jankowska, Katarzyna
collection PubMed
description Biochemical markers of spermatogenesis and fertility assessment are important in the practical management of infertile males and the determination of an individual’s prognosis. We performed an analysis on 100 males with a male infertility factor. The following study inclusion parameters were analyzed: seminogram, FSH, LH, testosterone, estradiol, prolactin, TSH, and inhibin B concentrations. The patients were subsequently treated by reproductive endocrinologists in accordance with AUA/ASRM and EAU guidelines. The reproductive status was evaluated over a period of 3 years. We found a strong correlation of sperm count with inhibin B (r = 0.74, p < 0.001) and FSH concentration levels (r = −0.46, p < 0.001). Among 95 patients at follow-up, pregnancies occurred for 59 of their partners (48 spontaneous, 5 after IVF–ET, and 6 after IUI). Thirty-six patients remained childless despite the therapy. Sperm count and inhibin B level were the best predictors of natural fertilization (ROC AUC: 0.86 and 0.84; cut-off: 2.7 mln/mL and 45 pg/mL). Although inhibin B and FSH can be used to evaluate spermatogenesis and fertility, the initial sperm concentration appeared to be the best predictor of success. Pregnancy was achieved in a surprisingly large proportion of patients with a very low concentration of inhibin B and a low initial sperm count. It is noteworthy that 81% of the pregnancies were achieved without medically assisted reproduction.
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spelling pubmed-90305432022-04-23 Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility Jankowska, Katarzyna Suszczewicz, Natalia Rabijewski, Michał Dudek, Piotr Zgliczyński, Wojciech Maksym, Radosław B. Life (Basel) Article Biochemical markers of spermatogenesis and fertility assessment are important in the practical management of infertile males and the determination of an individual’s prognosis. We performed an analysis on 100 males with a male infertility factor. The following study inclusion parameters were analyzed: seminogram, FSH, LH, testosterone, estradiol, prolactin, TSH, and inhibin B concentrations. The patients were subsequently treated by reproductive endocrinologists in accordance with AUA/ASRM and EAU guidelines. The reproductive status was evaluated over a period of 3 years. We found a strong correlation of sperm count with inhibin B (r = 0.74, p < 0.001) and FSH concentration levels (r = −0.46, p < 0.001). Among 95 patients at follow-up, pregnancies occurred for 59 of their partners (48 spontaneous, 5 after IVF–ET, and 6 after IUI). Thirty-six patients remained childless despite the therapy. Sperm count and inhibin B level were the best predictors of natural fertilization (ROC AUC: 0.86 and 0.84; cut-off: 2.7 mln/mL and 45 pg/mL). Although inhibin B and FSH can be used to evaluate spermatogenesis and fertility, the initial sperm concentration appeared to be the best predictor of success. Pregnancy was achieved in a surprisingly large proportion of patients with a very low concentration of inhibin B and a low initial sperm count. It is noteworthy that 81% of the pregnancies were achieved without medically assisted reproduction. MDPI 2022-03-30 /pmc/articles/PMC9030543/ /pubmed/35455002 http://dx.doi.org/10.3390/life12040511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jankowska, Katarzyna
Suszczewicz, Natalia
Rabijewski, Michał
Dudek, Piotr
Zgliczyński, Wojciech
Maksym, Radosław B.
Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility
title Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility
title_full Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility
title_fullStr Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility
title_full_unstemmed Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility
title_short Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility
title_sort inhibin-b and fsh are good indicators of spermatogenesis but not the best indicators of fertility
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030543/
https://www.ncbi.nlm.nih.gov/pubmed/35455002
http://dx.doi.org/10.3390/life12040511
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