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Vertebral Osteomyelitis and Infective Endocarditis Co-Infection

Many cases of vertebral osteomyelitis (VO) and infective endocarditis (IE) co-infection have been reported, and it has been recognized that attention should be paid to the possibility of both diseases co-existing during diagnosis and treatment. However, the incidence, clinical status, and outcomes o...

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Autores principales: Morimoto, Tadatsugu, Hirata, Hirohito, Otani, Koji, Nakamura, Eiichiro, Miyakoshi, Naohisa, Terashima, Yoshinori, Wada, Kanichiro, Kobayashi, Takaomi, Murayama, Masatoshi, Tsukamoto, Masatsugu, Mawatari, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030611/
https://www.ncbi.nlm.nih.gov/pubmed/35456361
http://dx.doi.org/10.3390/jcm11082266
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author Morimoto, Tadatsugu
Hirata, Hirohito
Otani, Koji
Nakamura, Eiichiro
Miyakoshi, Naohisa
Terashima, Yoshinori
Wada, Kanichiro
Kobayashi, Takaomi
Murayama, Masatoshi
Tsukamoto, Masatsugu
Mawatari, Masaaki
author_facet Morimoto, Tadatsugu
Hirata, Hirohito
Otani, Koji
Nakamura, Eiichiro
Miyakoshi, Naohisa
Terashima, Yoshinori
Wada, Kanichiro
Kobayashi, Takaomi
Murayama, Masatoshi
Tsukamoto, Masatsugu
Mawatari, Masaaki
author_sort Morimoto, Tadatsugu
collection PubMed
description Many cases of vertebral osteomyelitis (VO) and infective endocarditis (IE) co-infection have been reported, and it has been recognized that attention should be paid to the possibility of both diseases co-existing during diagnosis and treatment. However, the incidence, clinical status, and outcomes of IE in patients with VO remain unclear. For this study, the eligibility criteria for patient recruitment included all cases of VO at the five medical university hospitals. Patients with a history of spinal surgery were excluded from this study. Echocardiography was routinely performed for all patients with VO. IE was diagnosed according to the modified Duke criteria for definite endocarditis. We analyzed demographic data, underlying conditions, clinical features, laboratory data, echocardiography, radiologic images, treatments, and outcomes. VO was diagnosed in 59 patients and IE was diagnosed in seven patients (12%). There were no significant differences in the clinical features, microorganisms, or radiographic status between the VO-IE co-infection and VO-only groups. In this study, using routine echocardiography for VO, the IE prevalence was 12%. The lack of specific clinical features and laboratory findings may hamper the diagnosis of IE. Therefore, clinicians are always required to suspect IE in patients with VO.
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spelling pubmed-90306112022-04-23 Vertebral Osteomyelitis and Infective Endocarditis Co-Infection Morimoto, Tadatsugu Hirata, Hirohito Otani, Koji Nakamura, Eiichiro Miyakoshi, Naohisa Terashima, Yoshinori Wada, Kanichiro Kobayashi, Takaomi Murayama, Masatoshi Tsukamoto, Masatsugu Mawatari, Masaaki J Clin Med Article Many cases of vertebral osteomyelitis (VO) and infective endocarditis (IE) co-infection have been reported, and it has been recognized that attention should be paid to the possibility of both diseases co-existing during diagnosis and treatment. However, the incidence, clinical status, and outcomes of IE in patients with VO remain unclear. For this study, the eligibility criteria for patient recruitment included all cases of VO at the five medical university hospitals. Patients with a history of spinal surgery were excluded from this study. Echocardiography was routinely performed for all patients with VO. IE was diagnosed according to the modified Duke criteria for definite endocarditis. We analyzed demographic data, underlying conditions, clinical features, laboratory data, echocardiography, radiologic images, treatments, and outcomes. VO was diagnosed in 59 patients and IE was diagnosed in seven patients (12%). There were no significant differences in the clinical features, microorganisms, or radiographic status between the VO-IE co-infection and VO-only groups. In this study, using routine echocardiography for VO, the IE prevalence was 12%. The lack of specific clinical features and laboratory findings may hamper the diagnosis of IE. Therefore, clinicians are always required to suspect IE in patients with VO. MDPI 2022-04-18 /pmc/articles/PMC9030611/ /pubmed/35456361 http://dx.doi.org/10.3390/jcm11082266 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morimoto, Tadatsugu
Hirata, Hirohito
Otani, Koji
Nakamura, Eiichiro
Miyakoshi, Naohisa
Terashima, Yoshinori
Wada, Kanichiro
Kobayashi, Takaomi
Murayama, Masatoshi
Tsukamoto, Masatsugu
Mawatari, Masaaki
Vertebral Osteomyelitis and Infective Endocarditis Co-Infection
title Vertebral Osteomyelitis and Infective Endocarditis Co-Infection
title_full Vertebral Osteomyelitis and Infective Endocarditis Co-Infection
title_fullStr Vertebral Osteomyelitis and Infective Endocarditis Co-Infection
title_full_unstemmed Vertebral Osteomyelitis and Infective Endocarditis Co-Infection
title_short Vertebral Osteomyelitis and Infective Endocarditis Co-Infection
title_sort vertebral osteomyelitis and infective endocarditis co-infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030611/
https://www.ncbi.nlm.nih.gov/pubmed/35456361
http://dx.doi.org/10.3390/jcm11082266
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