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Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD

OIRD (opioid-induced respiratory depression) remains a significant public health concern due to clinically indicated and illicit opioid use. Respiratory depression is the sine qua non of opioid toxicity, and early detection is critical for reversal using pharmacologic and non-pharmacologic intervent...

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Autores principales: Singh, Naveen K., Sidhu, Gurpreet K., Gupta, Kuldeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030757/
https://www.ncbi.nlm.nih.gov/pubmed/35453493
http://dx.doi.org/10.3390/biomedicines10040743
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author Singh, Naveen K.
Sidhu, Gurpreet K.
Gupta, Kuldeep
author_facet Singh, Naveen K.
Sidhu, Gurpreet K.
Gupta, Kuldeep
author_sort Singh, Naveen K.
collection PubMed
description OIRD (opioid-induced respiratory depression) remains a significant public health concern due to clinically indicated and illicit opioid use. Respiratory depression is the sine qua non of opioid toxicity, and early detection is critical for reversal using pharmacologic and non-pharmacologic interventions. In addition to respiratory monitoring devices such as pulse oximetry, capnography, and contactless monitoring systems, novel implantable sensors and detection systems such as optical detection and electrochemical detection techniques are being developed to identify the presence of opioids both in vivo and within the environment. These new technologies will not only monitor for signs and symptoms of OIRD but also serve as a mechanism to alert and assist first responders and lay rescuers. The current opioid epidemic brings to the forefront the need for additional accessible means of detection and diagnosis. Rigorous evaluation of safety, efficacy, and acceptability will be necessary for both new and established technologies to have an impact on morbidity and mortality associated with opioid toxicity. Here, we summarized existing and advanced technologies for opioid detection and OIRD management with a focus on recent advancements in wearable and implantable opioid detection. We expect that this review will serve as a complete informative reference for the researchers and healthcare professionals working on the subject and allied fields.
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spelling pubmed-90307572022-04-23 Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD Singh, Naveen K. Sidhu, Gurpreet K. Gupta, Kuldeep Biomedicines Review OIRD (opioid-induced respiratory depression) remains a significant public health concern due to clinically indicated and illicit opioid use. Respiratory depression is the sine qua non of opioid toxicity, and early detection is critical for reversal using pharmacologic and non-pharmacologic interventions. In addition to respiratory monitoring devices such as pulse oximetry, capnography, and contactless monitoring systems, novel implantable sensors and detection systems such as optical detection and electrochemical detection techniques are being developed to identify the presence of opioids both in vivo and within the environment. These new technologies will not only monitor for signs and symptoms of OIRD but also serve as a mechanism to alert and assist first responders and lay rescuers. The current opioid epidemic brings to the forefront the need for additional accessible means of detection and diagnosis. Rigorous evaluation of safety, efficacy, and acceptability will be necessary for both new and established technologies to have an impact on morbidity and mortality associated with opioid toxicity. Here, we summarized existing and advanced technologies for opioid detection and OIRD management with a focus on recent advancements in wearable and implantable opioid detection. We expect that this review will serve as a complete informative reference for the researchers and healthcare professionals working on the subject and allied fields. MDPI 2022-03-22 /pmc/articles/PMC9030757/ /pubmed/35453493 http://dx.doi.org/10.3390/biomedicines10040743 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Singh, Naveen K.
Sidhu, Gurpreet K.
Gupta, Kuldeep
Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD
title Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD
title_full Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD
title_fullStr Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD
title_full_unstemmed Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD
title_short Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD
title_sort current and future perspective of devices and diagnostics for opioid and oird
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030757/
https://www.ncbi.nlm.nih.gov/pubmed/35453493
http://dx.doi.org/10.3390/biomedicines10040743
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