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Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD
OIRD (opioid-induced respiratory depression) remains a significant public health concern due to clinically indicated and illicit opioid use. Respiratory depression is the sine qua non of opioid toxicity, and early detection is critical for reversal using pharmacologic and non-pharmacologic intervent...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030757/ https://www.ncbi.nlm.nih.gov/pubmed/35453493 http://dx.doi.org/10.3390/biomedicines10040743 |
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author | Singh, Naveen K. Sidhu, Gurpreet K. Gupta, Kuldeep |
author_facet | Singh, Naveen K. Sidhu, Gurpreet K. Gupta, Kuldeep |
author_sort | Singh, Naveen K. |
collection | PubMed |
description | OIRD (opioid-induced respiratory depression) remains a significant public health concern due to clinically indicated and illicit opioid use. Respiratory depression is the sine qua non of opioid toxicity, and early detection is critical for reversal using pharmacologic and non-pharmacologic interventions. In addition to respiratory monitoring devices such as pulse oximetry, capnography, and contactless monitoring systems, novel implantable sensors and detection systems such as optical detection and electrochemical detection techniques are being developed to identify the presence of opioids both in vivo and within the environment. These new technologies will not only monitor for signs and symptoms of OIRD but also serve as a mechanism to alert and assist first responders and lay rescuers. The current opioid epidemic brings to the forefront the need for additional accessible means of detection and diagnosis. Rigorous evaluation of safety, efficacy, and acceptability will be necessary for both new and established technologies to have an impact on morbidity and mortality associated with opioid toxicity. Here, we summarized existing and advanced technologies for opioid detection and OIRD management with a focus on recent advancements in wearable and implantable opioid detection. We expect that this review will serve as a complete informative reference for the researchers and healthcare professionals working on the subject and allied fields. |
format | Online Article Text |
id | pubmed-9030757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90307572022-04-23 Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD Singh, Naveen K. Sidhu, Gurpreet K. Gupta, Kuldeep Biomedicines Review OIRD (opioid-induced respiratory depression) remains a significant public health concern due to clinically indicated and illicit opioid use. Respiratory depression is the sine qua non of opioid toxicity, and early detection is critical for reversal using pharmacologic and non-pharmacologic interventions. In addition to respiratory monitoring devices such as pulse oximetry, capnography, and contactless monitoring systems, novel implantable sensors and detection systems such as optical detection and electrochemical detection techniques are being developed to identify the presence of opioids both in vivo and within the environment. These new technologies will not only monitor for signs and symptoms of OIRD but also serve as a mechanism to alert and assist first responders and lay rescuers. The current opioid epidemic brings to the forefront the need for additional accessible means of detection and diagnosis. Rigorous evaluation of safety, efficacy, and acceptability will be necessary for both new and established technologies to have an impact on morbidity and mortality associated with opioid toxicity. Here, we summarized existing and advanced technologies for opioid detection and OIRD management with a focus on recent advancements in wearable and implantable opioid detection. We expect that this review will serve as a complete informative reference for the researchers and healthcare professionals working on the subject and allied fields. MDPI 2022-03-22 /pmc/articles/PMC9030757/ /pubmed/35453493 http://dx.doi.org/10.3390/biomedicines10040743 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Singh, Naveen K. Sidhu, Gurpreet K. Gupta, Kuldeep Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD |
title | Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD |
title_full | Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD |
title_fullStr | Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD |
title_full_unstemmed | Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD |
title_short | Current and Future Perspective of Devices and Diagnostics for Opioid and OIRD |
title_sort | current and future perspective of devices and diagnostics for opioid and oird |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030757/ https://www.ncbi.nlm.nih.gov/pubmed/35453493 http://dx.doi.org/10.3390/biomedicines10040743 |
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