Cargando…

Hypothiocyanous Acid Disrupts the Barrier Function of Brain Endothelial Cells

Inflammation is a common feature of neurological diseases. During neuroinflammation, neutrophils are recruited to the brain vasculature, where myeloperoxidase can produce hypochlorous acid and the less well-studied oxidant hypothiocyanous acid (HOSCN). In this study, we exposed primary brain endothe...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Leeuwen, Eveline, Hampton, Mark B., Smyth, Leon C. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030776/ https://www.ncbi.nlm.nih.gov/pubmed/35453292 http://dx.doi.org/10.3390/antiox11040608

Ejemplares similares

Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis
por: Bozonet, Stephanie M., et al.
Publicado: (2023)

A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid
por: Shearer, Heather L., et al.
Publicado: (2022)

Response of Pseudomonas aeruginosa to the Innate Immune System-Derived Oxidants Hypochlorous Acid and Hypothiocyanous Acid
por: Farrant, Katie V., et al.
Publicado: (2020)

The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages
por: Love, Dominic T., et al.
Publicado: (2020)

Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage
por: Skaff, Ojia, et al.
Publicado: (2011)

Interplay of Plasmodium falciparum and thrombin in brain endothelial barrier disruption
por: Avril, Marion, et al.
Publicado: (2019)

Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation
por: Tunon-Ortiz, Arnulfo, et al.
Publicado: (2019)

Biosensor Technology Reveals the Disruption of the Endothelial Barrier Function and the Subsequent Death of Blood Brain Barrier Endothelial Cells to Sodium Azide and Its Gaseous Products
por: Kho, Dan T., et al.
Publicado: (2017)

Analysis of Melanoma Secretome for Factors That Directly Disrupt the Barrier Integrity of Brain Endothelial Cells
por: Anchan, Akshata, et al.
Publicado: (2020)

Zika Virus Infects, Activates, and Crosses Brain Microvascular Endothelial Cells, without Barrier Disruption
por: Papa, Michelle P., et al.
Publicado: (2017)

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study
por: Palmela, Inês, et al.
Publicado: (2015)

Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
por: Kim, Brandon J., et al.
Publicado: (2019)

Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function
por: Raghavan, Somasundaram, et al.
Publicado: (2022)

The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections
por: Maiuolo, Jessica, et al.
Publicado: (2018)

Acid sphingomyelinase-mediated blood-brain barrier disruption in aging
por: Park, Min Hee, et al.
Publicado: (2019)

Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity
por: Marchi, Nicola, et al.
Publicado: (2010)

Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a
por: Tiwary, Shweta, et al.
Publicado: (2018)

Acute ocular hypertension disrupts barrier integrity and pump function in rat corneal endothelial cells
por: Li, Xian, et al.
Publicado: (2017)

Hantavirus-induced disruption of the endothelial barrier: neutrophils are on the payroll
por: Schönrich, Günther, et al.
Publicado: (2015)

MAP Kinase Pathways in Brain Endothelial Cells and Crosstalk with Pericytes and Astrocytes Mediate Contrast-Induced Blood–Brain Barrier Disruption
por: Matsunaga, Yuki, et al.
Publicado: (2021)

Direct Current Stimulation Disrupts Endothelial Glycocalyx and Tight Junctions of the Blood-Brain Barrier in vitro
por: Xia, Yifan, et al.
Publicado: (2021)

Melanoma Mediated Disruption of Brain Endothelial Barrier Integrity Is Not Prevented by the Inhibition of Matrix Metalloproteinases and Proteases
por: Anchan, Akshata, et al.
Publicado: (2022)

Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils
por: Schindler, Lisa, et al.
Publicado: (2021)

Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development
por: Chatterjee, Ishita, et al.
Publicado: (2016)

Disruption of Vascular Barriers in Tumors and in the Brain
por: McDannold, Nathan
Publicado: (2015)

Epigenetics in blood–brain barrier disruption
por: Ihezie, Stephanie A., et al.
Publicado: (2021)

EphB3 signaling induces cortical endothelial cell death and disrupts the blood–brain barrier after traumatic brain injury
por: Assis-Nascimento, Poincyane, et al.
Publicado: (2018)

Gold nanoparticles disrupt actin organization and pulmonary endothelial barriers
por: Sinclair, Whitney E., et al.
Publicado: (2020)

A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells
por: Ma, Zhe, et al.
Publicado: (2019)

Plasma Extracellular Vesicles in Children with OSA Disrupt Blood–Brain Barrier Integrity and Endothelial Cell Wound Healing In Vitro
por: Khalyfa, Abdelnaby, et al.
Publicado: (2019)

Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro
por: Lei, Yuxuan, et al.
Publicado: (2023)

Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells
por: Eustaquio Do Imperio, Guinever, et al.
Publicado: (2021)

Endothelial AHR activity prevents lung barrier disruption in viral infection
por: Major, Jack, et al.
Publicado: (2023)

Blood-brain barrier regulation: Environmental cues controlling the onset of barrier properties
por: Mizee, Mark Ronald, et al.
Publicado: (2013)

State-of-the-art of microbubble-assisted blood-brain barrier disruption
por: Song, Kang-Ho, et al.
Publicado: (2018)

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
por: Shi, Yejie, et al.
Publicado: (2016)

Pathomechanisms of Blood-Brain Barrier Disruption in ALS
por: Kakaroubas, Nicholas, et al.
Publicado: (2019)

Melanoma Cells Produce Large Vesicular-Bodies That Cause Rapid Disruption of Brain Endothelial Barrier-Integrity and Disassembly of Junctional Proteins
por: Spurling, Dayna, et al.
Publicado: (2023)

Membrane vesicle delivery of a streptococcal M protein disrupts the blood–brain barrier by inducing autophagic endothelial cell death
por: Pan, Fei, et al.
Publicado: (2023)

Glucocorticoids and endothelial cell barrier function
por: Salvador, Ellaine, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_34sor3aa7lp79uufhacavshoqr