Cargando…

The Calcium Channel Subunit Gamma-4 as a Novel Regulator of MafA in Pancreatic Beta-Cell Controls Glucose Homeostasis

Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are high-risk factors of diabetes development and may be caused by defective insulin secretion in pancreatic beta-cells. Glucose-stimulated insulin secretion is mediated by voltage-gated Ca(2+) (Ca(V)) channels in which the gamma-4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Rui, Karagiannopoulos, Alexandros, Eliasson, Lena, Renström, Erik, Luan, Cheng, Zhang, Enming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030882/ https://www.ncbi.nlm.nih.gov/pubmed/35453520 http://dx.doi.org/10.3390/biomedicines10040770

Ejemplares similares

The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification
por: Luan, Cheng, et al.
Publicado: (2019)

MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets
por: Singh, Tania, et al.
Publicado: (2018)

Loss of MafA and MafB expression promotes islet inflammation
por: Singh, Tania, et al.
Publicado: (2019)

MafB Maintains β-Cell Identity under MafA-Deficient Conditions
por: Deng, Zhaobin, et al.
Publicado: (2022)

miRNAs in the Beta Cell—Friends or Foes?
por: Karagiannopoulos, Alexandros, et al.
Publicado: (2023)

MafA Is Required for Postnatal Proliferation of Pancreatic β-Cells
por: Eto, Koki, et al.
Publicado: (2014)

Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta Cells
por: Arcidiacono, Biagio, et al.
Publicado: (2015)

MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
por: Artner, Isabella, et al.
Publicado: (2010)

MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition
por: Xiafukaiti, Gulibaikelamu, et al.
Publicado: (2019)

Correction: MafA Is Required for Postnatal Proliferation of Pancreatic β-Cells
Publicado: (2014)

MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes
por: Ganic, Elvira, et al.
Publicado: (2016)

MafA is a Key Molecule in Glucose and Energy Balance in the Central Nervous System and Peripheral Organs
por: Tsuchiya, Mariko, et al.
Publicado: (2011)

Reprogramming of Various Cell Types to a Beta-Like State by Pdx1, Ngn3 and MafA
por: Akinci, Ersin, et al.
Publicado: (2013)

An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition
por: Deng, Zhaobin, et al.
Publicado: (2020)

MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms
por: Liang, Jiani, et al.
Publicado: (2022)

A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells
por: Ye, Yingying, et al.
Publicado: (2022)

Generation of Insulin-Expressing Cells in Mouse Small Intestine by Pdx1, MafA, and BETA2/NeuroD
por: Lee, So-Hyun, et al.
Publicado: (2017)

MafA and MafB Regulate Pdx1 Transcription through the Area II Control Region in Pancreatic β Cells
por: Vanhoose, Amanda M., et al.
Publicado: (2008)

Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes
por: Matsuoka, Taka-aki, et al.
Publicado: (2010)

The highly expressed calcium‐insensitive synaptotagmin‐11 and synaptotagmin‐13 modulate insulin secretion
por: Ofori, Jones K., et al.
Publicado: (2022)

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
por: Hang, Yan, et al.
Publicado: (2014)

Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA
por: Akinci, Ersin, et al.
Publicado: (2012)

The outer-membrane protein MafA of Neisseria meningitidis constitutes a novel protein secretion pathway specific for the fratricide protein MafB
por: Arenas, Jesús, et al.
Publicado: (2020)

Protein therapy using MafA fused to a polyarginine transduction domain attenuates glucose levels of streptozotocin-induced diabetic mice
por: Lu, Jun, et al.
Publicado: (2017)

Insulin Transactivator MafA Regulates Intrathymic Expression of Insulin and Affects Susceptibility to Type 1 Diabetes
por: Noso, Shinsuke, et al.
Publicado: (2010)

MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin(+) cells
por: Chiou, Shih-Hwa, et al.
Publicado: (2011)

Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
por: Zhu, Ke, et al.
Publicado: (2020)

Adenoviruses Expressing PDX-1, BETA2/NeuroD and MafA Induces the Transdifferentiation of Porcine Neonatal Pancreas Cell Clusters and Adult Pig Pancreatic Cells into Beta-Cells
por: You, Young-Hye, et al.
Publicado: (2011)

Eukaryotic Translation Initiation Factor 3 Subunit E Controls Intracellular Calcium Homeostasis by Regulation of Cav1.2 Surface Expression
por: Buda, Pawel, et al.
Publicado: (2013)

TAT-Mediated Transduction of MafA Protein In Utero Results in Enhanced Pancreatic Insulin Expression and Changes in Islet Morphology
por: Vargas, Nancy, et al.
Publicado: (2011)

Expression Profiling of Pdx1, Ngn3, and MafA in the Liver and Pancreas of Recovering Streptozotocin-Induced Diabetic Rats
por: Al-Adsani, Amani M., et al.
Publicado: (2022)

Specific reprogramming of alpha cells to insulin-producing cells by short glucagon promoter-driven Pdx1 and MafA
por: Guo, Ping, et al.
Publicado: (2023)

Generation of Functional Insulin-Producing Cells from Neonatal Porcine Liver-Derived Cells by PDX1/VP16, BETA2/NeuroD and MafA
por: Ham, Dong-Sik, et al.
Publicado: (2013)

A Short-activating RNA Oligonucleotide Targeting the Islet β-cell Transcriptional Factor MafA in CD34(+) Cells
por: Reebye, Vikash, et al.
Publicado: (2013)

Transcriptome analysis of human brain microvascular endothelial cells response to Neisseria meningitidis and its antigen MafA using RNA-seq
por: Káňová, Evelína, et al.
Publicado: (2019)

Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
por: Esguerra, Jonathan L.S., et al.
Publicado: (2019)

MafA Overexpression: A New Efficient Protocol for In Vitro Differentiation of Adipose-Derived Mesenchymal Stem Cells into Functional Insulin-Producing Cells
por: Dayer, Dian, et al.
Publicado: (2019)

Pax4 synergistically acts with Pdx1, Ngn3 and MafA to induce HuMSCs to differentiate into functional pancreatic β-cells
por: Zhang, Ting, et al.
Publicado: (2019)

Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves β-Cell Mass and Function in ZDF Rats
por: Mahadevan, Jana, et al.
Publicado: (2013)

The m(6)A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic β Cells by Regulating MafA Expression
por: Cheng, Yi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6199c2uenge0uha611pqugd2pu