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Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation
Recent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier ex...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030991/ https://www.ncbi.nlm.nih.gov/pubmed/35458414 http://dx.doi.org/10.3390/v14040684 |
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author | Welch, David Buonanno, Manuela Buchan, Andrew G. Yang, Liang Atkinson, Kirk D. Shuryak, Igor Brenner, David J. |
author_facet | Welch, David Buonanno, Manuela Buchan, Andrew G. Yang, Liang Atkinson, Kirk D. Shuryak, Igor Brenner, David J. |
author_sort | Welch, David |
collection | PubMed |
description | Recent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose–response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose–response relation, and the estimated susceptibility constant at low doses—the relevant parameter for realistic low dose rate exposures—was 12.4 ± 0.4 cm(2)/mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens. |
format | Online Article Text |
id | pubmed-9030991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90309912022-04-23 Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation Welch, David Buonanno, Manuela Buchan, Andrew G. Yang, Liang Atkinson, Kirk D. Shuryak, Igor Brenner, David J. Viruses Article Recent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose–response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose–response relation, and the estimated susceptibility constant at low doses—the relevant parameter for realistic low dose rate exposures—was 12.4 ± 0.4 cm(2)/mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens. MDPI 2022-03-25 /pmc/articles/PMC9030991/ /pubmed/35458414 http://dx.doi.org/10.3390/v14040684 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Welch, David Buonanno, Manuela Buchan, Andrew G. Yang, Liang Atkinson, Kirk D. Shuryak, Igor Brenner, David J. Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation |
title | Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation |
title_full | Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation |
title_fullStr | Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation |
title_full_unstemmed | Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation |
title_short | Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation |
title_sort | inactivation rates for airborne human coronavirus by low doses of 222 nm far-uvc radiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030991/ https://www.ncbi.nlm.nih.gov/pubmed/35458414 http://dx.doi.org/10.3390/v14040684 |
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