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Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation

Recent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier ex...

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Autores principales: Welch, David, Buonanno, Manuela, Buchan, Andrew G., Yang, Liang, Atkinson, Kirk D., Shuryak, Igor, Brenner, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030991/
https://www.ncbi.nlm.nih.gov/pubmed/35458414
http://dx.doi.org/10.3390/v14040684
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author Welch, David
Buonanno, Manuela
Buchan, Andrew G.
Yang, Liang
Atkinson, Kirk D.
Shuryak, Igor
Brenner, David J.
author_facet Welch, David
Buonanno, Manuela
Buchan, Andrew G.
Yang, Liang
Atkinson, Kirk D.
Shuryak, Igor
Brenner, David J.
author_sort Welch, David
collection PubMed
description Recent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose–response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose–response relation, and the estimated susceptibility constant at low doses—the relevant parameter for realistic low dose rate exposures—was 12.4 ± 0.4 cm(2)/mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens.
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spelling pubmed-90309912022-04-23 Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation Welch, David Buonanno, Manuela Buchan, Andrew G. Yang, Liang Atkinson, Kirk D. Shuryak, Igor Brenner, David J. Viruses Article Recent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose–response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose–response relation, and the estimated susceptibility constant at low doses—the relevant parameter for realistic low dose rate exposures—was 12.4 ± 0.4 cm(2)/mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens. MDPI 2022-03-25 /pmc/articles/PMC9030991/ /pubmed/35458414 http://dx.doi.org/10.3390/v14040684 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Welch, David
Buonanno, Manuela
Buchan, Andrew G.
Yang, Liang
Atkinson, Kirk D.
Shuryak, Igor
Brenner, David J.
Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation
title Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation
title_full Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation
title_fullStr Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation
title_full_unstemmed Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation
title_short Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation
title_sort inactivation rates for airborne human coronavirus by low doses of 222 nm far-uvc radiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030991/
https://www.ncbi.nlm.nih.gov/pubmed/35458414
http://dx.doi.org/10.3390/v14040684
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