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Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study

This prospective comparative case series aims to compare best-corrected visual acuity (BCVA), retinal microvasculature, and retinal structural changes in patients treated with either ranibizumab or aflibercept for macular edema (ME) secondary to treatment-naïve branch retinal vein occlusion (BRVO) b...

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Autores principales: Huang, Yu-Te, Wang, I, Lin, Chun-Ju, Lai, Chun-Ting, Hsia, Ning-Yi, Chen, Huan-Sheng, Tien, Peng-Tai, Bair, Henry, Lin, Jane-Ming, Chen, Wen-Lu, Chen, Chang-He, Wu, Wen-Chuan, Tsai, Yi-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031043/
https://www.ncbi.nlm.nih.gov/pubmed/35454378
http://dx.doi.org/10.3390/medicina58040540
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author Huang, Yu-Te
Wang, I
Lin, Chun-Ju
Lai, Chun-Ting
Hsia, Ning-Yi
Chen, Huan-Sheng
Tien, Peng-Tai
Bair, Henry
Lin, Jane-Ming
Chen, Wen-Lu
Chen, Chang-He
Wu, Wen-Chuan
Tsai, Yi-Yu
author_facet Huang, Yu-Te
Wang, I
Lin, Chun-Ju
Lai, Chun-Ting
Hsia, Ning-Yi
Chen, Huan-Sheng
Tien, Peng-Tai
Bair, Henry
Lin, Jane-Ming
Chen, Wen-Lu
Chen, Chang-He
Wu, Wen-Chuan
Tsai, Yi-Yu
author_sort Huang, Yu-Te
collection PubMed
description This prospective comparative case series aims to compare best-corrected visual acuity (BCVA), retinal microvasculature, and retinal structural changes in patients treated with either ranibizumab or aflibercept for macular edema (ME) secondary to treatment-naïve branch retinal vein occlusion (BRVO) by optical coherence tomography angiography (OCTA). Ten patients were enrolled with macular capillary density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and foveal avascular zone (FAZ) measured in both eyes before and after treatment. Final central retinal thickness and BCVA improved significantly (p < 0.05), and densities of SCP and DCP of BRVO sectors were significantly lower at baseline than fellow eye counterparts and remained persistently lower during treatment, particularly in the aflibercept group (p < 0.05). SCP density, DCP density of both BRVO sectors (p = 0.0001, p < 0.0001), and non-BRVO sectors (p < 0.0001, p < 0.0001) were significantly correlated with final BCVA for diseased eyes. Using multivariate general linear model analysis, and including OCTA parameters only, but not all of the available clinical data, DCP density of BRVO sectors in both eyes was the most predictive factor for final visual outcome (probability p < 0.0001). OCTA offered further qualitative and quantitative evaluation of treatment-naïve BRVO. Judging by OCTA parameters, not only in the diseased eye but also in the fellow eye, DCP density of BRVO sectors was the most predictive factor of final visual outcome.
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spelling pubmed-90310432022-04-23 Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study Huang, Yu-Te Wang, I Lin, Chun-Ju Lai, Chun-Ting Hsia, Ning-Yi Chen, Huan-Sheng Tien, Peng-Tai Bair, Henry Lin, Jane-Ming Chen, Wen-Lu Chen, Chang-He Wu, Wen-Chuan Tsai, Yi-Yu Medicina (Kaunas) Article This prospective comparative case series aims to compare best-corrected visual acuity (BCVA), retinal microvasculature, and retinal structural changes in patients treated with either ranibizumab or aflibercept for macular edema (ME) secondary to treatment-naïve branch retinal vein occlusion (BRVO) by optical coherence tomography angiography (OCTA). Ten patients were enrolled with macular capillary density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and foveal avascular zone (FAZ) measured in both eyes before and after treatment. Final central retinal thickness and BCVA improved significantly (p < 0.05), and densities of SCP and DCP of BRVO sectors were significantly lower at baseline than fellow eye counterparts and remained persistently lower during treatment, particularly in the aflibercept group (p < 0.05). SCP density, DCP density of both BRVO sectors (p = 0.0001, p < 0.0001), and non-BRVO sectors (p < 0.0001, p < 0.0001) were significantly correlated with final BCVA for diseased eyes. Using multivariate general linear model analysis, and including OCTA parameters only, but not all of the available clinical data, DCP density of BRVO sectors in both eyes was the most predictive factor for final visual outcome (probability p < 0.0001). OCTA offered further qualitative and quantitative evaluation of treatment-naïve BRVO. Judging by OCTA parameters, not only in the diseased eye but also in the fellow eye, DCP density of BRVO sectors was the most predictive factor of final visual outcome. MDPI 2022-04-14 /pmc/articles/PMC9031043/ /pubmed/35454378 http://dx.doi.org/10.3390/medicina58040540 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Yu-Te
Wang, I
Lin, Chun-Ju
Lai, Chun-Ting
Hsia, Ning-Yi
Chen, Huan-Sheng
Tien, Peng-Tai
Bair, Henry
Lin, Jane-Ming
Chen, Wen-Lu
Chen, Chang-He
Wu, Wen-Chuan
Tsai, Yi-Yu
Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study
title Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study
title_full Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study
title_fullStr Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study
title_full_unstemmed Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study
title_short Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study
title_sort comparison of choroidal thickness, foveal avascular zone, and macular capillary density in macular edema secondary to branch retinal vein occlusion treated with ranibizumab or aflibercept—a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031043/
https://www.ncbi.nlm.nih.gov/pubmed/35454378
http://dx.doi.org/10.3390/medicina58040540
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