High Cell Density Cultivation Process for the Expression of Botulinum Neurotoxin a Receptor Binding Domain

The receptor-binding domain of botulinum neurotoxin (H(C) fragment), is a promising botulism vaccine candidate. In the current study, fermentation strategies were evaluated to upscale H(C) fragment expression. A simple translation of the growth conditions from shake flasks to a batch fermentation pr...

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Detalles Bibliográficos
Autores principales: Ben David, Alon, Papir, Yoel, Hazan, Ophir, Redelman, Moses, Diamant, Eran, Barnea, Ada, Torgeman, Amram, Zichel, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031141/
https://www.ncbi.nlm.nih.gov/pubmed/35448890
http://dx.doi.org/10.3390/toxins14040281

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