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Two Consecutive Prolines in the Fusion Peptide of Murine β-Coronavirus Spike Protein Predominantly Determine Fusogenicity and May Be Essential but Not Sufficient to Cause Demyelination

Combined in silico, in vitro, and in vivo comparative studies between isogenic-recombinant Mouse-Hepatitis-Virus-RSA59 and its proline deletion mutant, revealed a remarkable contribution of centrally located two consecutive prolines (PP) from Spike protein fusion peptide (FP) in enhancing virus fuso...

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Detalles Bibliográficos
Autores principales:	Safiriyu, Abass Alao, Singh, Manmeet, Kishore, Abhinoy, Mulchandani, Vaishali, Maity, Dibyajyoti, Behera, Amrutamaya, Sinha, Bidisha, Pal, Debnath, Das Sarma, Jayasri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031231/ https://www.ncbi.nlm.nih.gov/pubmed/35458565 http://dx.doi.org/10.3390/v14040834

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