New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum

Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (1–7), along with the known analogue cladosporiumin D (8), were obtained from the extract of the deep-sea-derived fungus Lecanicillium fusisporum GXIMD00542 within the family Clavipitacae. Their structures were elucidate...

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Autores principales: Xu, Xinya, Tan, Yanhui, Gao, Chenghai, Liu, Kai, Tang, Zhenzhou, Lu, Chunju, Li, Haiyan, Zhang, Xiaoyong, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031249/
https://www.ncbi.nlm.nih.gov/pubmed/35447928
http://dx.doi.org/10.3390/md20040255
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author Xu, Xinya
Tan, Yanhui
Gao, Chenghai
Liu, Kai
Tang, Zhenzhou
Lu, Chunju
Li, Haiyan
Zhang, Xiaoyong
Liu, Yonghong
author_facet Xu, Xinya
Tan, Yanhui
Gao, Chenghai
Liu, Kai
Tang, Zhenzhou
Lu, Chunju
Li, Haiyan
Zhang, Xiaoyong
Liu, Yonghong
author_sort Xu, Xinya
collection PubMed
description Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (1–7), along with the known analogue cladosporiumin D (8), were obtained from the extract of the deep-sea-derived fungus Lecanicillium fusisporum GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds 1, 2, 5–7 exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC(50) values range of 18.49–30.19 μM.
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spelling pubmed-90312492022-04-23 New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum Xu, Xinya Tan, Yanhui Gao, Chenghai Liu, Kai Tang, Zhenzhou Lu, Chunju Li, Haiyan Zhang, Xiaoyong Liu, Yonghong Mar Drugs Article Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (1–7), along with the known analogue cladosporiumin D (8), were obtained from the extract of the deep-sea-derived fungus Lecanicillium fusisporum GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds 1, 2, 5–7 exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC(50) values range of 18.49–30.19 μM. MDPI 2022-04-06 /pmc/articles/PMC9031249/ /pubmed/35447928 http://dx.doi.org/10.3390/md20040255 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Xinya
Tan, Yanhui
Gao, Chenghai
Liu, Kai
Tang, Zhenzhou
Lu, Chunju
Li, Haiyan
Zhang, Xiaoyong
Liu, Yonghong
New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum
title New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum
title_full New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum
title_fullStr New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum
title_full_unstemmed New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum
title_short New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum
title_sort new 3-acyl tetramic acid derivatives from the deep-sea-derived fungus lecanicillium fusisporum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031249/
https://www.ncbi.nlm.nih.gov/pubmed/35447928
http://dx.doi.org/10.3390/md20040255
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