Fighting Enteroviral Infections to Prevent Type 1 Diabetes

Enteroviruses (EVs), especially coxsackieviruses B (CVB), are believed to trigger or accelerate islet autoimmunity in genetically susceptible individuals that results in type 1 diabetes (T1D). Therefore, strategies are needed to fight against EV infections. There are no approved antiviral drugs curr...

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Autores principales: Nekoua, Magloire Pandoua, Mercier, Ambroise, Alhazmi, Abdulaziz, Sane, Famara, Alidjinou, Enagnon Kazali, Hober, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031364/
https://www.ncbi.nlm.nih.gov/pubmed/35456818
http://dx.doi.org/10.3390/microorganisms10040768
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author Nekoua, Magloire Pandoua
Mercier, Ambroise
Alhazmi, Abdulaziz
Sane, Famara
Alidjinou, Enagnon Kazali
Hober, Didier
author_facet Nekoua, Magloire Pandoua
Mercier, Ambroise
Alhazmi, Abdulaziz
Sane, Famara
Alidjinou, Enagnon Kazali
Hober, Didier
author_sort Nekoua, Magloire Pandoua
collection PubMed
description Enteroviruses (EVs), especially coxsackieviruses B (CVB), are believed to trigger or accelerate islet autoimmunity in genetically susceptible individuals that results in type 1 diabetes (T1D). Therefore, strategies are needed to fight against EV infections. There are no approved antiviral drugs currently available, but various antiviral drugs targeting viral or host cell proteins and vaccines have recently shown potential to combat CVB infections and may be used as new therapeutic strategies to prevent or reduce the risk of T1D and/or preserve β-cell function among patients with islet autoantibodies or T1D.
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spelling pubmed-90313642022-04-23 Fighting Enteroviral Infections to Prevent Type 1 Diabetes Nekoua, Magloire Pandoua Mercier, Ambroise Alhazmi, Abdulaziz Sane, Famara Alidjinou, Enagnon Kazali Hober, Didier Microorganisms Perspective Enteroviruses (EVs), especially coxsackieviruses B (CVB), are believed to trigger or accelerate islet autoimmunity in genetically susceptible individuals that results in type 1 diabetes (T1D). Therefore, strategies are needed to fight against EV infections. There are no approved antiviral drugs currently available, but various antiviral drugs targeting viral or host cell proteins and vaccines have recently shown potential to combat CVB infections and may be used as new therapeutic strategies to prevent or reduce the risk of T1D and/or preserve β-cell function among patients with islet autoantibodies or T1D. MDPI 2022-04-01 /pmc/articles/PMC9031364/ /pubmed/35456818 http://dx.doi.org/10.3390/microorganisms10040768 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Nekoua, Magloire Pandoua
Mercier, Ambroise
Alhazmi, Abdulaziz
Sane, Famara
Alidjinou, Enagnon Kazali
Hober, Didier
Fighting Enteroviral Infections to Prevent Type 1 Diabetes
title Fighting Enteroviral Infections to Prevent Type 1 Diabetes
title_full Fighting Enteroviral Infections to Prevent Type 1 Diabetes
title_fullStr Fighting Enteroviral Infections to Prevent Type 1 Diabetes
title_full_unstemmed Fighting Enteroviral Infections to Prevent Type 1 Diabetes
title_short Fighting Enteroviral Infections to Prevent Type 1 Diabetes
title_sort fighting enteroviral infections to prevent type 1 diabetes
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031364/
https://www.ncbi.nlm.nih.gov/pubmed/35456818
http://dx.doi.org/10.3390/microorganisms10040768
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