A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors

Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning thi...

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Autores principales: Abdelwahab, Ahmed Bakr, El-Sawy, Eslam Reda, Hanna, Atef G., Bagrel, Denyse, Kirsch, Gilbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031484/
https://www.ncbi.nlm.nih.gov/pubmed/35458583
http://dx.doi.org/10.3390/molecules27082389
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author Abdelwahab, Ahmed Bakr
El-Sawy, Eslam Reda
Hanna, Atef G.
Bagrel, Denyse
Kirsch, Gilbert
author_facet Abdelwahab, Ahmed Bakr
El-Sawy, Eslam Reda
Hanna, Atef G.
Bagrel, Denyse
Kirsch, Gilbert
author_sort Abdelwahab, Ahmed Bakr
collection PubMed
description Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue. An overview is constructed based on data analysis of the results of the previous publications covering the years from 1992 to 2021. Thus, the main objective of the current review is to report the chemical structures of Cdc25s inhibitors and answer the question, how to design an inhibitor with better efficacy and lower toxicity?
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spelling pubmed-90314842022-04-23 A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors Abdelwahab, Ahmed Bakr El-Sawy, Eslam Reda Hanna, Atef G. Bagrel, Denyse Kirsch, Gilbert Molecules Review Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue. An overview is constructed based on data analysis of the results of the previous publications covering the years from 1992 to 2021. Thus, the main objective of the current review is to report the chemical structures of Cdc25s inhibitors and answer the question, how to design an inhibitor with better efficacy and lower toxicity? MDPI 2022-04-07 /pmc/articles/PMC9031484/ /pubmed/35458583 http://dx.doi.org/10.3390/molecules27082389 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abdelwahab, Ahmed Bakr
El-Sawy, Eslam Reda
Hanna, Atef G.
Bagrel, Denyse
Kirsch, Gilbert
A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
title A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
title_full A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
title_fullStr A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
title_full_unstemmed A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
title_short A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
title_sort comprehensive overview of the developments of cdc25 phosphatase inhibitors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031484/
https://www.ncbi.nlm.nih.gov/pubmed/35458583
http://dx.doi.org/10.3390/molecules27082389
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