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Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0

Gestational diabetes mellitus (GDM) has become a major public health problem and one of the most discussed issues in modern obstetrics. GDM is associated with serious adverse perinatal outcomes and long-term health consequences for both the mother and child. Currently, the importance and purposefuln...

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Autores principales: Ruszała, Monika, Pilszyk, Aleksandra, Niebrzydowska, Magdalena, Kimber-Trojnar, Żaneta, Trojnar, Marcin, Leszczyńska-Gorzelak, Bożena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031541/
https://www.ncbi.nlm.nih.gov/pubmed/35457182
http://dx.doi.org/10.3390/ijms23084364
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author Ruszała, Monika
Pilszyk, Aleksandra
Niebrzydowska, Magdalena
Kimber-Trojnar, Żaneta
Trojnar, Marcin
Leszczyńska-Gorzelak, Bożena
author_facet Ruszała, Monika
Pilszyk, Aleksandra
Niebrzydowska, Magdalena
Kimber-Trojnar, Żaneta
Trojnar, Marcin
Leszczyńska-Gorzelak, Bożena
author_sort Ruszała, Monika
collection PubMed
description Gestational diabetes mellitus (GDM) has become a major public health problem and one of the most discussed issues in modern obstetrics. GDM is associated with serious adverse perinatal outcomes and long-term health consequences for both the mother and child. Currently, the importance and purposefulness of finding a biopredictor that will enable the identification of women with an increased risk of developing GDM as early as the beginning of pregnancy are highly emphasized. Both “older” molecules, such as adiponectin and leptin, and “newer” adipokines, including fatty acid-binding protein 4 (FABP4), have proven to be of pathophysiological importance in GDM. Therefore, in our previous review, we presented 13 novel biomolecules, i.e., galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, FABP4, fibroblast growth factor 21, and lipocalin-2. The purpose of this review is to present the potential and importance of another nine lesser known molecules in the pathogenesis of GDM, i.e., 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), angiopoietin-like protein-8 (ANGPTL-8), nesfatin-1, afamin, adropin, fetuin-A, zonulin, secreted frizzled-related proteins (SFRPs), and amylin. It seems that two of them, fetuin-A and zonulin in high serum levels, may be applied as biopredictors of GDM.
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spelling pubmed-90315412022-04-23 Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0 Ruszała, Monika Pilszyk, Aleksandra Niebrzydowska, Magdalena Kimber-Trojnar, Żaneta Trojnar, Marcin Leszczyńska-Gorzelak, Bożena Int J Mol Sci Review Gestational diabetes mellitus (GDM) has become a major public health problem and one of the most discussed issues in modern obstetrics. GDM is associated with serious adverse perinatal outcomes and long-term health consequences for both the mother and child. Currently, the importance and purposefulness of finding a biopredictor that will enable the identification of women with an increased risk of developing GDM as early as the beginning of pregnancy are highly emphasized. Both “older” molecules, such as adiponectin and leptin, and “newer” adipokines, including fatty acid-binding protein 4 (FABP4), have proven to be of pathophysiological importance in GDM. Therefore, in our previous review, we presented 13 novel biomolecules, i.e., galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, FABP4, fibroblast growth factor 21, and lipocalin-2. The purpose of this review is to present the potential and importance of another nine lesser known molecules in the pathogenesis of GDM, i.e., 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), angiopoietin-like protein-8 (ANGPTL-8), nesfatin-1, afamin, adropin, fetuin-A, zonulin, secreted frizzled-related proteins (SFRPs), and amylin. It seems that two of them, fetuin-A and zonulin in high serum levels, may be applied as biopredictors of GDM. MDPI 2022-04-14 /pmc/articles/PMC9031541/ /pubmed/35457182 http://dx.doi.org/10.3390/ijms23084364 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ruszała, Monika
Pilszyk, Aleksandra
Niebrzydowska, Magdalena
Kimber-Trojnar, Żaneta
Trojnar, Marcin
Leszczyńska-Gorzelak, Bożena
Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0
title Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0
title_full Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0
title_fullStr Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0
title_full_unstemmed Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0
title_short Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0
title_sort novel biomolecules in the pathogenesis of gestational diabetes mellitus 2.0
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031541/
https://www.ncbi.nlm.nih.gov/pubmed/35457182
http://dx.doi.org/10.3390/ijms23084364
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