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Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases
Cardiac diseases are the leading causes of death, with a growing number of cases worldwide, posing a challenge for both healthcare and research. Therefore, the most relevant aim of cardiac research is to unravel the molecular pathomechanisms and identify new therapeutic targets. Cardiac ryanodine re...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031589/ https://www.ncbi.nlm.nih.gov/pubmed/35457253 http://dx.doi.org/10.3390/ijms23084435 |
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author | Szentandrássy, Norbert Magyar, Zsuzsanna É. Hevesi, Judit Bányász, Tamás Nánási, Péter P. Almássy, János |
author_facet | Szentandrássy, Norbert Magyar, Zsuzsanna É. Hevesi, Judit Bányász, Tamás Nánási, Péter P. Almássy, János |
author_sort | Szentandrássy, Norbert |
collection | PubMed |
description | Cardiac diseases are the leading causes of death, with a growing number of cases worldwide, posing a challenge for both healthcare and research. Therefore, the most relevant aim of cardiac research is to unravel the molecular pathomechanisms and identify new therapeutic targets. Cardiac ryanodine receptor (RyR2), the Ca(2+) release channel of the sarcoplasmic reticulum, is believed to be a good therapeutic target in a group of certain heart diseases, collectively called cardiac ryanopathies. Ryanopathies are associated with the impaired function of the RyR, leading to heart diseases such as congestive heart failure (CHF), catecholaminergic polymorphic ventricular tachycardia (CPVT), arrhythmogenic right ventricular dysplasia type 2 (ARVD2), and calcium release deficiency syndrome (CRDS). The aim of the current review is to provide a short insight into the pathological mechanisms of ryanopathies and discuss the pharmacological approaches targeting RyR2. |
format | Online Article Text |
id | pubmed-9031589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90315892022-04-23 Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases Szentandrássy, Norbert Magyar, Zsuzsanna É. Hevesi, Judit Bányász, Tamás Nánási, Péter P. Almássy, János Int J Mol Sci Review Cardiac diseases are the leading causes of death, with a growing number of cases worldwide, posing a challenge for both healthcare and research. Therefore, the most relevant aim of cardiac research is to unravel the molecular pathomechanisms and identify new therapeutic targets. Cardiac ryanodine receptor (RyR2), the Ca(2+) release channel of the sarcoplasmic reticulum, is believed to be a good therapeutic target in a group of certain heart diseases, collectively called cardiac ryanopathies. Ryanopathies are associated with the impaired function of the RyR, leading to heart diseases such as congestive heart failure (CHF), catecholaminergic polymorphic ventricular tachycardia (CPVT), arrhythmogenic right ventricular dysplasia type 2 (ARVD2), and calcium release deficiency syndrome (CRDS). The aim of the current review is to provide a short insight into the pathological mechanisms of ryanopathies and discuss the pharmacological approaches targeting RyR2. MDPI 2022-04-18 /pmc/articles/PMC9031589/ /pubmed/35457253 http://dx.doi.org/10.3390/ijms23084435 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szentandrássy, Norbert Magyar, Zsuzsanna É. Hevesi, Judit Bányász, Tamás Nánási, Péter P. Almássy, János Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases |
title | Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases |
title_full | Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases |
title_fullStr | Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases |
title_full_unstemmed | Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases |
title_short | Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases |
title_sort | therapeutic approaches of ryanodine receptor-associated heart diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031589/ https://www.ncbi.nlm.nih.gov/pubmed/35457253 http://dx.doi.org/10.3390/ijms23084435 |
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