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Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study

Device-assisted enteroscopy (DAE) enables the direct visualization of small bowel lesions with histological diagnosis; however, few studies have described the diagnostic performance of enteroscopic biopsy. We investigated the diagnostic performance of enteroscopic biopsy. We used a nationwide multic...

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Autores principales: Goong, Hyeon Jeong, Kim, Tae Joon, Nam, Kwangwoo, Park, Jihye, Kim, Jin-Oh, Kim, Hyun Gun, Ko, Bong Min, Jeon, Seong Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031609/
https://www.ncbi.nlm.nih.gov/pubmed/35454011
http://dx.doi.org/10.3390/diagnostics12040964
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author Goong, Hyeon Jeong
Kim, Tae Joon
Nam, Kwangwoo
Park, Jihye
Kim, Jin-Oh
Kim, Hyun Gun
Ko, Bong Min
Jeon, Seong Ran
author_facet Goong, Hyeon Jeong
Kim, Tae Joon
Nam, Kwangwoo
Park, Jihye
Kim, Jin-Oh
Kim, Hyun Gun
Ko, Bong Min
Jeon, Seong Ran
author_sort Goong, Hyeon Jeong
collection PubMed
description Device-assisted enteroscopy (DAE) enables the direct visualization of small bowel lesions with histological diagnosis; however, few studies have described the diagnostic performance of enteroscopic biopsy. We investigated the diagnostic performance of enteroscopic biopsy. We used a nationwide multicenter enteroscopy database to identify patients who underwent DAE with biopsy for small bowel diseases. The patients were classified into the tumor and non-tumor groups according to the final diagnosis. They were also divided into diagnostic and non-diagnostic groups based on the enteroscopic biopsy results. The clinical significance of the first biopsy and histological diagnostic yield of DAE were analyzed. Among the 112 procedures investigated, 32 (28.9%) were diagnosed with tumors, and 80 (71.7%) were diagnosed with non-tumor diseases. The overall histological diagnostic yield of DAE was 43.7%. The histological diagnostic yield was significantly higher in the tumor than in the non-tumor group (81.2% vs. 28.8%, p < 0.001). The mean number of biopsies was significantly higher in the diagnostic than in the non-diagnostic group (5.6 ± 3.3 vs. 3.7 ± 2.1, p = 0.001). In the diagnostic group, 87.7% of the cases were histologically confirmed at the first biopsy. Therefore, the first biopsy should be performed carefully.
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spelling pubmed-90316092022-04-23 Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study Goong, Hyeon Jeong Kim, Tae Joon Nam, Kwangwoo Park, Jihye Kim, Jin-Oh Kim, Hyun Gun Ko, Bong Min Jeon, Seong Ran Diagnostics (Basel) Article Device-assisted enteroscopy (DAE) enables the direct visualization of small bowel lesions with histological diagnosis; however, few studies have described the diagnostic performance of enteroscopic biopsy. We investigated the diagnostic performance of enteroscopic biopsy. We used a nationwide multicenter enteroscopy database to identify patients who underwent DAE with biopsy for small bowel diseases. The patients were classified into the tumor and non-tumor groups according to the final diagnosis. They were also divided into diagnostic and non-diagnostic groups based on the enteroscopic biopsy results. The clinical significance of the first biopsy and histological diagnostic yield of DAE were analyzed. Among the 112 procedures investigated, 32 (28.9%) were diagnosed with tumors, and 80 (71.7%) were diagnosed with non-tumor diseases. The overall histological diagnostic yield of DAE was 43.7%. The histological diagnostic yield was significantly higher in the tumor than in the non-tumor group (81.2% vs. 28.8%, p < 0.001). The mean number of biopsies was significantly higher in the diagnostic than in the non-diagnostic group (5.6 ± 3.3 vs. 3.7 ± 2.1, p = 0.001). In the diagnostic group, 87.7% of the cases were histologically confirmed at the first biopsy. Therefore, the first biopsy should be performed carefully. MDPI 2022-04-12 /pmc/articles/PMC9031609/ /pubmed/35454011 http://dx.doi.org/10.3390/diagnostics12040964 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Goong, Hyeon Jeong
Kim, Tae Joon
Nam, Kwangwoo
Park, Jihye
Kim, Jin-Oh
Kim, Hyun Gun
Ko, Bong Min
Jeon, Seong Ran
Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study
title Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study
title_full Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study
title_fullStr Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study
title_full_unstemmed Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study
title_short Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study
title_sort histological diagnostic yield and clinical significance of the first biopsy in device-assisted enteroscopy in patients with small bowel diseases: a kasid multicenter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031609/
https://www.ncbi.nlm.nih.gov/pubmed/35454011
http://dx.doi.org/10.3390/diagnostics12040964
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