Cargando…
Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study
Device-assisted enteroscopy (DAE) enables the direct visualization of small bowel lesions with histological diagnosis; however, few studies have described the diagnostic performance of enteroscopic biopsy. We investigated the diagnostic performance of enteroscopic biopsy. We used a nationwide multic...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031609/ https://www.ncbi.nlm.nih.gov/pubmed/35454011 http://dx.doi.org/10.3390/diagnostics12040964 |
_version_ | 1784692432756015104 |
---|---|
author | Goong, Hyeon Jeong Kim, Tae Joon Nam, Kwangwoo Park, Jihye Kim, Jin-Oh Kim, Hyun Gun Ko, Bong Min Jeon, Seong Ran |
author_facet | Goong, Hyeon Jeong Kim, Tae Joon Nam, Kwangwoo Park, Jihye Kim, Jin-Oh Kim, Hyun Gun Ko, Bong Min Jeon, Seong Ran |
author_sort | Goong, Hyeon Jeong |
collection | PubMed |
description | Device-assisted enteroscopy (DAE) enables the direct visualization of small bowel lesions with histological diagnosis; however, few studies have described the diagnostic performance of enteroscopic biopsy. We investigated the diagnostic performance of enteroscopic biopsy. We used a nationwide multicenter enteroscopy database to identify patients who underwent DAE with biopsy for small bowel diseases. The patients were classified into the tumor and non-tumor groups according to the final diagnosis. They were also divided into diagnostic and non-diagnostic groups based on the enteroscopic biopsy results. The clinical significance of the first biopsy and histological diagnostic yield of DAE were analyzed. Among the 112 procedures investigated, 32 (28.9%) were diagnosed with tumors, and 80 (71.7%) were diagnosed with non-tumor diseases. The overall histological diagnostic yield of DAE was 43.7%. The histological diagnostic yield was significantly higher in the tumor than in the non-tumor group (81.2% vs. 28.8%, p < 0.001). The mean number of biopsies was significantly higher in the diagnostic than in the non-diagnostic group (5.6 ± 3.3 vs. 3.7 ± 2.1, p = 0.001). In the diagnostic group, 87.7% of the cases were histologically confirmed at the first biopsy. Therefore, the first biopsy should be performed carefully. |
format | Online Article Text |
id | pubmed-9031609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90316092022-04-23 Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study Goong, Hyeon Jeong Kim, Tae Joon Nam, Kwangwoo Park, Jihye Kim, Jin-Oh Kim, Hyun Gun Ko, Bong Min Jeon, Seong Ran Diagnostics (Basel) Article Device-assisted enteroscopy (DAE) enables the direct visualization of small bowel lesions with histological diagnosis; however, few studies have described the diagnostic performance of enteroscopic biopsy. We investigated the diagnostic performance of enteroscopic biopsy. We used a nationwide multicenter enteroscopy database to identify patients who underwent DAE with biopsy for small bowel diseases. The patients were classified into the tumor and non-tumor groups according to the final diagnosis. They were also divided into diagnostic and non-diagnostic groups based on the enteroscopic biopsy results. The clinical significance of the first biopsy and histological diagnostic yield of DAE were analyzed. Among the 112 procedures investigated, 32 (28.9%) were diagnosed with tumors, and 80 (71.7%) were diagnosed with non-tumor diseases. The overall histological diagnostic yield of DAE was 43.7%. The histological diagnostic yield was significantly higher in the tumor than in the non-tumor group (81.2% vs. 28.8%, p < 0.001). The mean number of biopsies was significantly higher in the diagnostic than in the non-diagnostic group (5.6 ± 3.3 vs. 3.7 ± 2.1, p = 0.001). In the diagnostic group, 87.7% of the cases were histologically confirmed at the first biopsy. Therefore, the first biopsy should be performed carefully. MDPI 2022-04-12 /pmc/articles/PMC9031609/ /pubmed/35454011 http://dx.doi.org/10.3390/diagnostics12040964 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Goong, Hyeon Jeong Kim, Tae Joon Nam, Kwangwoo Park, Jihye Kim, Jin-Oh Kim, Hyun Gun Ko, Bong Min Jeon, Seong Ran Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study |
title | Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study |
title_full | Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study |
title_fullStr | Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study |
title_full_unstemmed | Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study |
title_short | Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study |
title_sort | histological diagnostic yield and clinical significance of the first biopsy in device-assisted enteroscopy in patients with small bowel diseases: a kasid multicenter study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031609/ https://www.ncbi.nlm.nih.gov/pubmed/35454011 http://dx.doi.org/10.3390/diagnostics12040964 |
work_keys_str_mv | AT goonghyeonjeong histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy AT kimtaejoon histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy AT namkwangwoo histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy AT parkjihye histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy AT kimjinoh histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy AT kimhyungun histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy AT kobongmin histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy AT jeonseongran histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy AT histologicaldiagnosticyieldandclinicalsignificanceofthefirstbiopsyindeviceassistedenteroscopyinpatientswithsmallboweldiseasesakasidmulticenterstudy |