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TLR4 Signaling and Heme Oxygenase-1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment

Relapse in multiple myeloma (MM) decreases therapy efficiency through unclear mechanisms of chemoresistance. Since our group previously demonstrated that heme oxygenase-1 (HO-1) and Toll-like receptor 4 (TLR4) are two signaling pathways protecting MM cells from the proteasome inhibitor bortezomib (B...

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Detalles Bibliográficos
Autores principales:	Scandura, Grazia, Giallongo, Cesarina, Puglisi, Fabrizio, Romano, Alessandra, Parrinello, Nunziatina Laura, Zuppelli, Tatiana, Longhitano, Lucia, Giallongo, Sebastiano, Di Rosa, Michelino, Musumeci, Giuseppe, Motterlini, Roberto, Foresti, Roberta, Palumbo, Giuseppe Alberto, Li Volti, Giovanni, Di Raimondo, Francesco, Tibullo, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031632/ https://www.ncbi.nlm.nih.gov/pubmed/35453452 http://dx.doi.org/10.3390/antiox11040767

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