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Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience

We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed...

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Autores principales: Nyk, Łukasz, Kamecki, Hubert, Krajewski, Wojciech, Małkiewicz, Bartosz, Szydełko, Tomasz, Kubis, Markiian, Słojewski, Marcin, Kryst, Piotr, Poletajew, Sławomir, Malewski, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031841/
https://www.ncbi.nlm.nih.gov/pubmed/35448723
http://dx.doi.org/10.3390/tomography8020089
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author Nyk, Łukasz
Kamecki, Hubert
Krajewski, Wojciech
Małkiewicz, Bartosz
Szydełko, Tomasz
Kubis, Markiian
Słojewski, Marcin
Kryst, Piotr
Poletajew, Sławomir
Malewski, Wojciech
author_facet Nyk, Łukasz
Kamecki, Hubert
Krajewski, Wojciech
Małkiewicz, Bartosz
Szydełko, Tomasz
Kubis, Markiian
Słojewski, Marcin
Kryst, Piotr
Poletajew, Sławomir
Malewski, Wojciech
author_sort Nyk, Łukasz
collection PubMed
description We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed by salvage lymph node dissection (SLND) in three academic centers between 2013 and 2020. A total of 27 men were included in the analyses. Sensitivity, specificity, positive and negative predictive values, and accuracy of choline-PET/CT in predicting pathology-proven lymph node involvement were 75%, 43%, 79%, 38% and 67% on per-patient and 70%, 86%, 80%, 78%, and 79% on per-site analyses, respectively, with the differences in specificity and NPV between per-patient and per-site analyses being statistically significant (p = 0.03 and 0.04, respectively). The study provides further insight into the role of preoperative choline-PET/CT in patients undergoing SLND for recurrent PC.
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spelling pubmed-90318412022-04-23 Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience Nyk, Łukasz Kamecki, Hubert Krajewski, Wojciech Małkiewicz, Bartosz Szydełko, Tomasz Kubis, Markiian Słojewski, Marcin Kryst, Piotr Poletajew, Sławomir Malewski, Wojciech Tomography Communication We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed by salvage lymph node dissection (SLND) in three academic centers between 2013 and 2020. A total of 27 men were included in the analyses. Sensitivity, specificity, positive and negative predictive values, and accuracy of choline-PET/CT in predicting pathology-proven lymph node involvement were 75%, 43%, 79%, 38% and 67% on per-patient and 70%, 86%, 80%, 78%, and 79% on per-site analyses, respectively, with the differences in specificity and NPV between per-patient and per-site analyses being statistically significant (p = 0.03 and 0.04, respectively). The study provides further insight into the role of preoperative choline-PET/CT in patients undergoing SLND for recurrent PC. MDPI 2022-04-11 /pmc/articles/PMC9031841/ /pubmed/35448723 http://dx.doi.org/10.3390/tomography8020089 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Nyk, Łukasz
Kamecki, Hubert
Krajewski, Wojciech
Małkiewicz, Bartosz
Szydełko, Tomasz
Kubis, Markiian
Słojewski, Marcin
Kryst, Piotr
Poletajew, Sławomir
Malewski, Wojciech
Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience
title Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience
title_full Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience
title_fullStr Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience
title_full_unstemmed Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience
title_short Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience
title_sort diagnostic performance of preoperative choline-pet/ct in patients undergoing salvage lymph node dissection for recurrent prostate cancer: a multicenter experience
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031841/
https://www.ncbi.nlm.nih.gov/pubmed/35448723
http://dx.doi.org/10.3390/tomography8020089
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