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Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience
We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031841/ https://www.ncbi.nlm.nih.gov/pubmed/35448723 http://dx.doi.org/10.3390/tomography8020089 |
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author | Nyk, Łukasz Kamecki, Hubert Krajewski, Wojciech Małkiewicz, Bartosz Szydełko, Tomasz Kubis, Markiian Słojewski, Marcin Kryst, Piotr Poletajew, Sławomir Malewski, Wojciech |
author_facet | Nyk, Łukasz Kamecki, Hubert Krajewski, Wojciech Małkiewicz, Bartosz Szydełko, Tomasz Kubis, Markiian Słojewski, Marcin Kryst, Piotr Poletajew, Sławomir Malewski, Wojciech |
author_sort | Nyk, Łukasz |
collection | PubMed |
description | We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed by salvage lymph node dissection (SLND) in three academic centers between 2013 and 2020. A total of 27 men were included in the analyses. Sensitivity, specificity, positive and negative predictive values, and accuracy of choline-PET/CT in predicting pathology-proven lymph node involvement were 75%, 43%, 79%, 38% and 67% on per-patient and 70%, 86%, 80%, 78%, and 79% on per-site analyses, respectively, with the differences in specificity and NPV between per-patient and per-site analyses being statistically significant (p = 0.03 and 0.04, respectively). The study provides further insight into the role of preoperative choline-PET/CT in patients undergoing SLND for recurrent PC. |
format | Online Article Text |
id | pubmed-9031841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90318412022-04-23 Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience Nyk, Łukasz Kamecki, Hubert Krajewski, Wojciech Małkiewicz, Bartosz Szydełko, Tomasz Kubis, Markiian Słojewski, Marcin Kryst, Piotr Poletajew, Sławomir Malewski, Wojciech Tomography Communication We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed by salvage lymph node dissection (SLND) in three academic centers between 2013 and 2020. A total of 27 men were included in the analyses. Sensitivity, specificity, positive and negative predictive values, and accuracy of choline-PET/CT in predicting pathology-proven lymph node involvement were 75%, 43%, 79%, 38% and 67% on per-patient and 70%, 86%, 80%, 78%, and 79% on per-site analyses, respectively, with the differences in specificity and NPV between per-patient and per-site analyses being statistically significant (p = 0.03 and 0.04, respectively). The study provides further insight into the role of preoperative choline-PET/CT in patients undergoing SLND for recurrent PC. MDPI 2022-04-11 /pmc/articles/PMC9031841/ /pubmed/35448723 http://dx.doi.org/10.3390/tomography8020089 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Nyk, Łukasz Kamecki, Hubert Krajewski, Wojciech Małkiewicz, Bartosz Szydełko, Tomasz Kubis, Markiian Słojewski, Marcin Kryst, Piotr Poletajew, Sławomir Malewski, Wojciech Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience |
title | Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience |
title_full | Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience |
title_fullStr | Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience |
title_full_unstemmed | Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience |
title_short | Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience |
title_sort | diagnostic performance of preoperative choline-pet/ct in patients undergoing salvage lymph node dissection for recurrent prostate cancer: a multicenter experience |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031841/ https://www.ncbi.nlm.nih.gov/pubmed/35448723 http://dx.doi.org/10.3390/tomography8020089 |
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