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Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction

Background and objectives: Adenocarcinoma of the esophagogastric junction (AEG) has a complicated surgical anatomy, due to which it sometimes induces excessive intraoperative blood loss that necessitates intraoperative blood transfusion (BTF). However, few reports have focused on the impact of BTF o...

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Autores principales: Nakajima, Kei, Tokunaga, Masanori, Okuno, Keisuke, Saito, Katsumasa, Fujiwara, Naoto, Sato, Yuya, Hoshino, Akihiro, Matsuyama, Takatoshi, Kinugasa, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031906/
https://www.ncbi.nlm.nih.gov/pubmed/35454312
http://dx.doi.org/10.3390/medicina58040474
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author Nakajima, Kei
Tokunaga, Masanori
Okuno, Keisuke
Saito, Katsumasa
Fujiwara, Naoto
Sato, Yuya
Hoshino, Akihiro
Matsuyama, Takatoshi
Kinugasa, Yusuke
author_facet Nakajima, Kei
Tokunaga, Masanori
Okuno, Keisuke
Saito, Katsumasa
Fujiwara, Naoto
Sato, Yuya
Hoshino, Akihiro
Matsuyama, Takatoshi
Kinugasa, Yusuke
author_sort Nakajima, Kei
collection PubMed
description Background and objectives: Adenocarcinoma of the esophagogastric junction (AEG) has a complicated surgical anatomy, due to which it sometimes induces excessive intraoperative blood loss that necessitates intraoperative blood transfusion (BTF). However, few reports have focused on the impact of BTF on the survival outcomes of patients with AEG. We aimed to evaluate the impact of BTF on AEG prognosis. Materials andMethods: We included 63 patients who underwent surgical resection for AEG at our hospital between January 2010 and September 2020. Clinicopathological characteristics and survival outcomes were compared between patients with (n = 12) and without (n = 51) BTF. Multivariate analysis was performed to identify the independent prognostic factors for overall survival. Results: None of the patients who underwent minimally invasive surgery received BTF. Patients who received BTF had a significantly worse 5-year survival rate than those who did not (67.8% vs. 28.3%, p = 0.001). BTF was an independent risk factor for overall survival (hazard ratio: 3.90, 95% confidence interval 1.30–11.7), even after patients who underwent minimally invasive surgery were excluded. Conclusions: BTF adversely affected the survival outcomes of patients with AEG who underwent curative surgery. To avoid BTF, surgeons should strive to minimize intraoperative bleeding.
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spelling pubmed-90319062022-04-23 Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction Nakajima, Kei Tokunaga, Masanori Okuno, Keisuke Saito, Katsumasa Fujiwara, Naoto Sato, Yuya Hoshino, Akihiro Matsuyama, Takatoshi Kinugasa, Yusuke Medicina (Kaunas) Article Background and objectives: Adenocarcinoma of the esophagogastric junction (AEG) has a complicated surgical anatomy, due to which it sometimes induces excessive intraoperative blood loss that necessitates intraoperative blood transfusion (BTF). However, few reports have focused on the impact of BTF on the survival outcomes of patients with AEG. We aimed to evaluate the impact of BTF on AEG prognosis. Materials andMethods: We included 63 patients who underwent surgical resection for AEG at our hospital between January 2010 and September 2020. Clinicopathological characteristics and survival outcomes were compared between patients with (n = 12) and without (n = 51) BTF. Multivariate analysis was performed to identify the independent prognostic factors for overall survival. Results: None of the patients who underwent minimally invasive surgery received BTF. Patients who received BTF had a significantly worse 5-year survival rate than those who did not (67.8% vs. 28.3%, p = 0.001). BTF was an independent risk factor for overall survival (hazard ratio: 3.90, 95% confidence interval 1.30–11.7), even after patients who underwent minimally invasive surgery were excluded. Conclusions: BTF adversely affected the survival outcomes of patients with AEG who underwent curative surgery. To avoid BTF, surgeons should strive to minimize intraoperative bleeding. MDPI 2022-03-25 /pmc/articles/PMC9031906/ /pubmed/35454312 http://dx.doi.org/10.3390/medicina58040474 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nakajima, Kei
Tokunaga, Masanori
Okuno, Keisuke
Saito, Katsumasa
Fujiwara, Naoto
Sato, Yuya
Hoshino, Akihiro
Matsuyama, Takatoshi
Kinugasa, Yusuke
Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction
title Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction
title_full Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction
title_fullStr Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction
title_full_unstemmed Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction
title_short Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction
title_sort prognostic value of intraoperative blood transfusion in patients with adenocarcinoma of the esophagogastric junction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031906/
https://www.ncbi.nlm.nih.gov/pubmed/35454312
http://dx.doi.org/10.3390/medicina58040474
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