Synthesis and biological evaluation of a new class of multi-target heterocycle piperazine derivatives as potential antipsychotics

In this study, we designed and synthesized a novel series of multi-receptor ligands as polypharmacological antipsychotic agents by using a multi-receptor affinity strategy. Among them, 3w combines a multi-receptor mechanism with high mixed affinities for D(2), 5-HT(1A), 5-HT(2A) and H(3) receptors,...

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Detalles Bibliográficos
Autores principales: Gao, Lanchang, Hao, Chao, Ma, Ru, Chen, Jiali, Zhang, Guisen, Chen, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031908/
https://www.ncbi.nlm.nih.gov/pubmed/35479681
http://dx.doi.org/10.1039/d1ra02426d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031908/
https://www.ncbi.nlm.nih.gov/pubmed/35479681
http://dx.doi.org/10.1039/d1ra02426d

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