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Synthesis and biological evaluation of a new class of multi-target heterocycle piperazine derivatives as potential antipsychotics
In this study, we designed and synthesized a novel series of multi-receptor ligands as polypharmacological antipsychotic agents by using a multi-receptor affinity strategy. Among them, 3w combines a multi-receptor mechanism with high mixed affinities for D(2), 5-HT(1A), 5-HT(2A) and H(3) receptors,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031908/ https://www.ncbi.nlm.nih.gov/pubmed/35479681 http://dx.doi.org/10.1039/d1ra02426d |