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Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer

Patients with non-small cell lung cancer, especially adenocarcinomas, harbour at least one oncogenic driver mutation that can potentially be a target for therapy. Treatments of these oncogene-addicted tumours, such as the use of tyrosine kinase inhibitors (TKIs) of mutated epidermal growth factor re...

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Autores principales: Calabrese, Fiorella, Pezzuto, Federica, Lunardi, Francesca, Fortarezza, Francesco, Tzorakoleftheraki, Sofia-Eleni, Resi, Maria Vittoria, Tiné, Mariaenrica, Pasello, Giulia, Hofman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031930/
https://www.ncbi.nlm.nih.gov/pubmed/35456982
http://dx.doi.org/10.3390/ijms23084164
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author Calabrese, Fiorella
Pezzuto, Federica
Lunardi, Francesca
Fortarezza, Francesco
Tzorakoleftheraki, Sofia-Eleni
Resi, Maria Vittoria
Tiné, Mariaenrica
Pasello, Giulia
Hofman, Paul
author_facet Calabrese, Fiorella
Pezzuto, Federica
Lunardi, Francesca
Fortarezza, Francesco
Tzorakoleftheraki, Sofia-Eleni
Resi, Maria Vittoria
Tiné, Mariaenrica
Pasello, Giulia
Hofman, Paul
author_sort Calabrese, Fiorella
collection PubMed
description Patients with non-small cell lung cancer, especially adenocarcinomas, harbour at least one oncogenic driver mutation that can potentially be a target for therapy. Treatments of these oncogene-addicted tumours, such as the use of tyrosine kinase inhibitors (TKIs) of mutated epidermal growth factor receptor, have dramatically improved the outcome of patients. However, some patients may acquire resistance to treatment early on after starting a targeted therapy. Transformations to other histotypes—small cell lung carcinoma, large cell neuroendocrine carcinoma, squamous cell carcinoma, and sarcomatoid carcinoma—have been increasingly recognised as important mechanisms of resistance and are increasingly becoming a topic of interest for all specialists involved in the diagnosis, management, and care of these patients. This article, after examining the most used TKI agents and their main biological activities, discusses histological and molecular transformations with an up-to-date review of all previous cases published in the field. Liquid biopsy and future research directions are also briefly discussed to offer the reader a complete and up-to-date overview of the topic.
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spelling pubmed-90319302022-04-23 Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer Calabrese, Fiorella Pezzuto, Federica Lunardi, Francesca Fortarezza, Francesco Tzorakoleftheraki, Sofia-Eleni Resi, Maria Vittoria Tiné, Mariaenrica Pasello, Giulia Hofman, Paul Int J Mol Sci Review Patients with non-small cell lung cancer, especially adenocarcinomas, harbour at least one oncogenic driver mutation that can potentially be a target for therapy. Treatments of these oncogene-addicted tumours, such as the use of tyrosine kinase inhibitors (TKIs) of mutated epidermal growth factor receptor, have dramatically improved the outcome of patients. However, some patients may acquire resistance to treatment early on after starting a targeted therapy. Transformations to other histotypes—small cell lung carcinoma, large cell neuroendocrine carcinoma, squamous cell carcinoma, and sarcomatoid carcinoma—have been increasingly recognised as important mechanisms of resistance and are increasingly becoming a topic of interest for all specialists involved in the diagnosis, management, and care of these patients. This article, after examining the most used TKI agents and their main biological activities, discusses histological and molecular transformations with an up-to-date review of all previous cases published in the field. Liquid biopsy and future research directions are also briefly discussed to offer the reader a complete and up-to-date overview of the topic. MDPI 2022-04-09 /pmc/articles/PMC9031930/ /pubmed/35456982 http://dx.doi.org/10.3390/ijms23084164 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Calabrese, Fiorella
Pezzuto, Federica
Lunardi, Francesca
Fortarezza, Francesco
Tzorakoleftheraki, Sofia-Eleni
Resi, Maria Vittoria
Tiné, Mariaenrica
Pasello, Giulia
Hofman, Paul
Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer
title Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer
title_full Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer
title_fullStr Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer
title_full_unstemmed Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer
title_short Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer
title_sort morphologic-molecular transformation of oncogene addicted non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031930/
https://www.ncbi.nlm.nih.gov/pubmed/35456982
http://dx.doi.org/10.3390/ijms23084164
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