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The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study

One of the major challenges for healthcare systems during the Coronavirus-2019 (COVID-19) pandemic was the inability to successfully predict which patients would require mechanical ventilation (MV). Angiotensin-Converting Enzyme 2 (ACE2) and TransMembrane Protease Serine S1 member 2 (TMPRSS2) are en...

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Autores principales: Kassif Lerner, Reut, Stein Yeshurun, Michal, Hemi, Rina, Zada, Nahid, Asraf, Keren, Doolman, Ram, Benoit, Stefanie W., Santos de Oliveira, Maria Helena, Lippi, Giuseppe, Henry, Brandon Michael, Pessach, Itai M., Pode Shakked, Naomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032089/
https://www.ncbi.nlm.nih.gov/pubmed/35455738
http://dx.doi.org/10.3390/jpm12040622
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author Kassif Lerner, Reut
Stein Yeshurun, Michal
Hemi, Rina
Zada, Nahid
Asraf, Keren
Doolman, Ram
Benoit, Stefanie W.
Santos de Oliveira, Maria Helena
Lippi, Giuseppe
Henry, Brandon Michael
Pessach, Itai M.
Pode Shakked, Naomi
author_facet Kassif Lerner, Reut
Stein Yeshurun, Michal
Hemi, Rina
Zada, Nahid
Asraf, Keren
Doolman, Ram
Benoit, Stefanie W.
Santos de Oliveira, Maria Helena
Lippi, Giuseppe
Henry, Brandon Michael
Pessach, Itai M.
Pode Shakked, Naomi
author_sort Kassif Lerner, Reut
collection PubMed
description One of the major challenges for healthcare systems during the Coronavirus-2019 (COVID-19) pandemic was the inability to successfully predict which patients would require mechanical ventilation (MV). Angiotensin-Converting Enzyme 2 (ACE2) and TransMembrane Protease Serine S1 member 2 (TMPRSS2) are enzymes that play crucial roles in SARS-CoV-2 entry into human host cells. However, their predictive value as biomarkers for risk stratification for respiratory deterioration requiring MV has not yet been evaluated. We aimed to evaluate whether serum ACE2 and TMPRSS2 levels are associated with adverse outcomes in COVID-19, and specifically the need for MV. COVID-19 patients admitted to an Israeli tertiary medical center between March--November 2020, were included. Serum samples were obtained shortly after admission (day 0) and again following one week of admission (day 7). ACE2 and TMPRSS2 concentrations were measured with ELISA. Of 72 patients included, 30 (41.6%) ultimately required MV. Serum ACE2 concentrations >7.8 ng/mL at admission were significantly associated with the need for MV (p = 0.036), inotropic support, and renal replacement therapy. In multivariate logistic regression analysis, elevated ACE2 at admission was associated with the need for MV (OR = 7.49; p = 0.014). To conclude, elevated serum ACE2 concentration early in COVID-19 illness correlates with respiratory failure necessitating mechanical ventilation. We suggest that measuring serum ACE2 at admission may be useful for predicting the risk of severe disease.
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spelling pubmed-90320892022-04-23 The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study Kassif Lerner, Reut Stein Yeshurun, Michal Hemi, Rina Zada, Nahid Asraf, Keren Doolman, Ram Benoit, Stefanie W. Santos de Oliveira, Maria Helena Lippi, Giuseppe Henry, Brandon Michael Pessach, Itai M. Pode Shakked, Naomi J Pers Med Article One of the major challenges for healthcare systems during the Coronavirus-2019 (COVID-19) pandemic was the inability to successfully predict which patients would require mechanical ventilation (MV). Angiotensin-Converting Enzyme 2 (ACE2) and TransMembrane Protease Serine S1 member 2 (TMPRSS2) are enzymes that play crucial roles in SARS-CoV-2 entry into human host cells. However, their predictive value as biomarkers for risk stratification for respiratory deterioration requiring MV has not yet been evaluated. We aimed to evaluate whether serum ACE2 and TMPRSS2 levels are associated with adverse outcomes in COVID-19, and specifically the need for MV. COVID-19 patients admitted to an Israeli tertiary medical center between March--November 2020, were included. Serum samples were obtained shortly after admission (day 0) and again following one week of admission (day 7). ACE2 and TMPRSS2 concentrations were measured with ELISA. Of 72 patients included, 30 (41.6%) ultimately required MV. Serum ACE2 concentrations >7.8 ng/mL at admission were significantly associated with the need for MV (p = 0.036), inotropic support, and renal replacement therapy. In multivariate logistic regression analysis, elevated ACE2 at admission was associated with the need for MV (OR = 7.49; p = 0.014). To conclude, elevated serum ACE2 concentration early in COVID-19 illness correlates with respiratory failure necessitating mechanical ventilation. We suggest that measuring serum ACE2 at admission may be useful for predicting the risk of severe disease. MDPI 2022-04-12 /pmc/articles/PMC9032089/ /pubmed/35455738 http://dx.doi.org/10.3390/jpm12040622 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kassif Lerner, Reut
Stein Yeshurun, Michal
Hemi, Rina
Zada, Nahid
Asraf, Keren
Doolman, Ram
Benoit, Stefanie W.
Santos de Oliveira, Maria Helena
Lippi, Giuseppe
Henry, Brandon Michael
Pessach, Itai M.
Pode Shakked, Naomi
The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study
title The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study
title_full The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study
title_fullStr The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study
title_full_unstemmed The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study
title_short The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study
title_sort predictive value of serum ace2 and tmprss2 concentrations in patients with covid-19—a prospective pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032089/
https://www.ncbi.nlm.nih.gov/pubmed/35455738
http://dx.doi.org/10.3390/jpm12040622
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