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Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions

Nickel is a heavy metal used in many industries. Nickel exposure can induce respiratory diseases and allergic reactions, and increase cancer risk. This study evaluated the introduction of a grinding and polishing system to prevent injuries from nickel toxicity in workers. We performed a controlled,...

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Autores principales: Kuo, Che-Yu, Lin, Cheng-Fu, Chung, Shih-Yu, Lin, Yu-Li, Chu, Wei-Min, Chen, Chun-Chieh, Tsan, Yu-Tse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032121/
https://www.ncbi.nlm.nih.gov/pubmed/35457753
http://dx.doi.org/10.3390/ijerph19084887
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author Kuo, Che-Yu
Lin, Cheng-Fu
Chung, Shih-Yu
Lin, Yu-Li
Chu, Wei-Min
Chen, Chun-Chieh
Tsan, Yu-Tse
author_facet Kuo, Che-Yu
Lin, Cheng-Fu
Chung, Shih-Yu
Lin, Yu-Li
Chu, Wei-Min
Chen, Chun-Chieh
Tsan, Yu-Tse
author_sort Kuo, Che-Yu
collection PubMed
description Nickel is a heavy metal used in many industries. Nickel exposure can induce respiratory diseases and allergic reactions, and increase cancer risk. This study evaluated the introduction of a grinding and polishing system to prevent injuries from nickel toxicity in workers. We performed a controlled, interventional, before-and-after study from January 2018 to December 2019 at a faucet component industrial manufacturing site. Results from workplace environmental monitoring, questionnaire responses, and biomonitoring were collected before and after the intervention. Thirty-seven workers (100% men) aged 25.0 (interquartile range (IQR): 22.0–33.5) years were categorized into two groups, those with and without nickel exposure. In the exposed group, the median exposure time was 18.0 months (IQR 14.0–20.0 months). Urinary nickel concentration was lower in the exposed group than in the non-exposed group (13.8 (IQR 1.7–20.7); 23.1 (IQR 11.3–32.8) μg/g creatinine, respectively; p = 0.047). The median urinary nickel concentration was lower in the second year than in the first year (17.4 (IQR 2.2–27.4), 7.7 (IQR 4.3–18.5) μg/g creatinine, respectively; p = 0.022). Significant reductions in urinary nickel concentration were observed following the intervention and educational program. Thus, biomonitoring of urinary nickel concentration can successfully reflect the effectiveness of interventions and their relationship to nickel exposure.
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spelling pubmed-90321212022-04-23 Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions Kuo, Che-Yu Lin, Cheng-Fu Chung, Shih-Yu Lin, Yu-Li Chu, Wei-Min Chen, Chun-Chieh Tsan, Yu-Tse Int J Environ Res Public Health Article Nickel is a heavy metal used in many industries. Nickel exposure can induce respiratory diseases and allergic reactions, and increase cancer risk. This study evaluated the introduction of a grinding and polishing system to prevent injuries from nickel toxicity in workers. We performed a controlled, interventional, before-and-after study from January 2018 to December 2019 at a faucet component industrial manufacturing site. Results from workplace environmental monitoring, questionnaire responses, and biomonitoring were collected before and after the intervention. Thirty-seven workers (100% men) aged 25.0 (interquartile range (IQR): 22.0–33.5) years were categorized into two groups, those with and without nickel exposure. In the exposed group, the median exposure time was 18.0 months (IQR 14.0–20.0 months). Urinary nickel concentration was lower in the exposed group than in the non-exposed group (13.8 (IQR 1.7–20.7); 23.1 (IQR 11.3–32.8) μg/g creatinine, respectively; p = 0.047). The median urinary nickel concentration was lower in the second year than in the first year (17.4 (IQR 2.2–27.4), 7.7 (IQR 4.3–18.5) μg/g creatinine, respectively; p = 0.022). Significant reductions in urinary nickel concentration were observed following the intervention and educational program. Thus, biomonitoring of urinary nickel concentration can successfully reflect the effectiveness of interventions and their relationship to nickel exposure. MDPI 2022-04-17 /pmc/articles/PMC9032121/ /pubmed/35457753 http://dx.doi.org/10.3390/ijerph19084887 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuo, Che-Yu
Lin, Cheng-Fu
Chung, Shih-Yu
Lin, Yu-Li
Chu, Wei-Min
Chen, Chun-Chieh
Tsan, Yu-Tse
Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions
title Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions
title_full Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions
title_fullStr Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions
title_full_unstemmed Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions
title_short Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions
title_sort biomonitoring of urinary nickel successfully protects employees and introduces effective interventions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032121/
https://www.ncbi.nlm.nih.gov/pubmed/35457753
http://dx.doi.org/10.3390/ijerph19084887
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