Heterologous Synthesis of Monacolin J by Reconstructing Its Biosynthetic Gene Cluster in Aspergillus niger

Monacolin J (MJ), a key precursor of Lovastatin, could synthesize important statin drug simvastatin by hydrolyzing lovastatin and adding different side chains. In this study, to reduce the cumbersome hydrolysis of lovastatin to produce MJ in the native strain Aspergillus terreus, the MJ biosynthetic...

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Detalles Bibliográficos
Autores principales: Zeng, Xu, Zheng, Junwei, Lu, Feifei, Pan, Li, Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032219/
https://www.ncbi.nlm.nih.gov/pubmed/35448638
http://dx.doi.org/10.3390/jof8040407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032219/
https://www.ncbi.nlm.nih.gov/pubmed/35448638
http://dx.doi.org/10.3390/jof8040407

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