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Integrating Sister Chromatid Cohesion Establishment to DNA Replication

The intersection through which two fundamental processes meet provides a unique vantage point from which to view cellular regulation. On the one hand, DNA replication is at the heart of cell division, generating duplicate chromosomes that allow each daughter cell to inherit a complete copy of the pa...

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Autores principales: Zuilkoski, Caitlin M., Skibbens, Robert V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032331/
https://www.ncbi.nlm.nih.gov/pubmed/35456431
http://dx.doi.org/10.3390/genes13040625
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author Zuilkoski, Caitlin M.
Skibbens, Robert V.
author_facet Zuilkoski, Caitlin M.
Skibbens, Robert V.
author_sort Zuilkoski, Caitlin M.
collection PubMed
description The intersection through which two fundamental processes meet provides a unique vantage point from which to view cellular regulation. On the one hand, DNA replication is at the heart of cell division, generating duplicate chromosomes that allow each daughter cell to inherit a complete copy of the parental genome. Among other factors, the PCNA (proliferating cell nuclear antigen) sliding clamp ensures processive DNA replication during S phase and is essential for cell viability. On the other hand, the process of chromosome segregation during M phase—an act that occurs long after DNA replication—is equally fundamental to a successful cell division. Eco1/Ctf7 ensures that chromosomes faithfully segregate during mitosis, but functions during DNA replication to activate cohesins and thereby establish cohesion between sister chromatids. To achieve this, Eco1 binds PCNA and numerous other DNA replication fork factors that include MCM helicase, Chl1 helicase, and the Rtt101-Mms1-Mms22 E3 ubiquitin ligase. Here, we review the multi-faceted coordination between cohesion establishment and DNA replication. SUMMARY STATEMENT: New findings provide important insights into the mechanisms through which DNA replication and the establishment of sister chromatid cohesion are coupled.
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spelling pubmed-90323312022-04-23 Integrating Sister Chromatid Cohesion Establishment to DNA Replication Zuilkoski, Caitlin M. Skibbens, Robert V. Genes (Basel) Review The intersection through which two fundamental processes meet provides a unique vantage point from which to view cellular regulation. On the one hand, DNA replication is at the heart of cell division, generating duplicate chromosomes that allow each daughter cell to inherit a complete copy of the parental genome. Among other factors, the PCNA (proliferating cell nuclear antigen) sliding clamp ensures processive DNA replication during S phase and is essential for cell viability. On the other hand, the process of chromosome segregation during M phase—an act that occurs long after DNA replication—is equally fundamental to a successful cell division. Eco1/Ctf7 ensures that chromosomes faithfully segregate during mitosis, but functions during DNA replication to activate cohesins and thereby establish cohesion between sister chromatids. To achieve this, Eco1 binds PCNA and numerous other DNA replication fork factors that include MCM helicase, Chl1 helicase, and the Rtt101-Mms1-Mms22 E3 ubiquitin ligase. Here, we review the multi-faceted coordination between cohesion establishment and DNA replication. SUMMARY STATEMENT: New findings provide important insights into the mechanisms through which DNA replication and the establishment of sister chromatid cohesion are coupled. MDPI 2022-03-31 /pmc/articles/PMC9032331/ /pubmed/35456431 http://dx.doi.org/10.3390/genes13040625 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zuilkoski, Caitlin M.
Skibbens, Robert V.
Integrating Sister Chromatid Cohesion Establishment to DNA Replication
title Integrating Sister Chromatid Cohesion Establishment to DNA Replication
title_full Integrating Sister Chromatid Cohesion Establishment to DNA Replication
title_fullStr Integrating Sister Chromatid Cohesion Establishment to DNA Replication
title_full_unstemmed Integrating Sister Chromatid Cohesion Establishment to DNA Replication
title_short Integrating Sister Chromatid Cohesion Establishment to DNA Replication
title_sort integrating sister chromatid cohesion establishment to dna replication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032331/
https://www.ncbi.nlm.nih.gov/pubmed/35456431
http://dx.doi.org/10.3390/genes13040625
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