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Vitamin D and Ocular Diseases: A Systematic Review

The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases...

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Autores principales: Chan, Hei-Nga, Zhang, Xiu-Juan, Ling, Xiang-Tian, Bui, Christine Huyen-Trang, Wang, Yu-Meng, Ip, Patrick, Chu, Wai-Kit, Chen, Li-Jia, Tham, Clement C., Yam, Jason C., Pang, Chi-Pui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032397/
https://www.ncbi.nlm.nih.gov/pubmed/35457041
http://dx.doi.org/10.3390/ijms23084226
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author Chan, Hei-Nga
Zhang, Xiu-Juan
Ling, Xiang-Tian
Bui, Christine Huyen-Trang
Wang, Yu-Meng
Ip, Patrick
Chu, Wai-Kit
Chen, Li-Jia
Tham, Clement C.
Yam, Jason C.
Pang, Chi-Pui
author_facet Chan, Hei-Nga
Zhang, Xiu-Juan
Ling, Xiang-Tian
Bui, Christine Huyen-Trang
Wang, Yu-Meng
Ip, Patrick
Chu, Wai-Kit
Chen, Li-Jia
Tham, Clement C.
Yam, Jason C.
Pang, Chi-Pui
author_sort Chan, Hei-Nga
collection PubMed
description The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), dry eye syndrome (DES), thyroid eye disease (TED), uveitis, retinoblastoma (RB), cataract, and others, from epidemiological, clinical and basic studies, and briefly discuss vitamin D metabolism in the eye. We searched two research databases for articles examining the association between vitamin D deficiency and different ocular diseases. One hundred and sixty-two studies were found. There is evidence on the association between vitamin D and myopia, AMD, DR, and DES. Overall, 17 out of 27 studies reported an association between vitamin D and AMD, while 48 out of 54 studies reported that vitamin D was associated with DR, and 25 out of 27 studies reported an association between vitamin D and DES. However, the available evidence for the association with other ocular diseases, such as glaucoma, TED, and RB, remains limited.
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spelling pubmed-90323972022-04-23 Vitamin D and Ocular Diseases: A Systematic Review Chan, Hei-Nga Zhang, Xiu-Juan Ling, Xiang-Tian Bui, Christine Huyen-Trang Wang, Yu-Meng Ip, Patrick Chu, Wai-Kit Chen, Li-Jia Tham, Clement C. Yam, Jason C. Pang, Chi-Pui Int J Mol Sci Review The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), dry eye syndrome (DES), thyroid eye disease (TED), uveitis, retinoblastoma (RB), cataract, and others, from epidemiological, clinical and basic studies, and briefly discuss vitamin D metabolism in the eye. We searched two research databases for articles examining the association between vitamin D deficiency and different ocular diseases. One hundred and sixty-two studies were found. There is evidence on the association between vitamin D and myopia, AMD, DR, and DES. Overall, 17 out of 27 studies reported an association between vitamin D and AMD, while 48 out of 54 studies reported that vitamin D was associated with DR, and 25 out of 27 studies reported an association between vitamin D and DES. However, the available evidence for the association with other ocular diseases, such as glaucoma, TED, and RB, remains limited. MDPI 2022-04-11 /pmc/articles/PMC9032397/ /pubmed/35457041 http://dx.doi.org/10.3390/ijms23084226 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chan, Hei-Nga
Zhang, Xiu-Juan
Ling, Xiang-Tian
Bui, Christine Huyen-Trang
Wang, Yu-Meng
Ip, Patrick
Chu, Wai-Kit
Chen, Li-Jia
Tham, Clement C.
Yam, Jason C.
Pang, Chi-Pui
Vitamin D and Ocular Diseases: A Systematic Review
title Vitamin D and Ocular Diseases: A Systematic Review
title_full Vitamin D and Ocular Diseases: A Systematic Review
title_fullStr Vitamin D and Ocular Diseases: A Systematic Review
title_full_unstemmed Vitamin D and Ocular Diseases: A Systematic Review
title_short Vitamin D and Ocular Diseases: A Systematic Review
title_sort vitamin d and ocular diseases: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032397/
https://www.ncbi.nlm.nih.gov/pubmed/35457041
http://dx.doi.org/10.3390/ijms23084226
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