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Vitamin D and Ocular Diseases: A Systematic Review
The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032397/ https://www.ncbi.nlm.nih.gov/pubmed/35457041 http://dx.doi.org/10.3390/ijms23084226 |
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author | Chan, Hei-Nga Zhang, Xiu-Juan Ling, Xiang-Tian Bui, Christine Huyen-Trang Wang, Yu-Meng Ip, Patrick Chu, Wai-Kit Chen, Li-Jia Tham, Clement C. Yam, Jason C. Pang, Chi-Pui |
author_facet | Chan, Hei-Nga Zhang, Xiu-Juan Ling, Xiang-Tian Bui, Christine Huyen-Trang Wang, Yu-Meng Ip, Patrick Chu, Wai-Kit Chen, Li-Jia Tham, Clement C. Yam, Jason C. Pang, Chi-Pui |
author_sort | Chan, Hei-Nga |
collection | PubMed |
description | The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), dry eye syndrome (DES), thyroid eye disease (TED), uveitis, retinoblastoma (RB), cataract, and others, from epidemiological, clinical and basic studies, and briefly discuss vitamin D metabolism in the eye. We searched two research databases for articles examining the association between vitamin D deficiency and different ocular diseases. One hundred and sixty-two studies were found. There is evidence on the association between vitamin D and myopia, AMD, DR, and DES. Overall, 17 out of 27 studies reported an association between vitamin D and AMD, while 48 out of 54 studies reported that vitamin D was associated with DR, and 25 out of 27 studies reported an association between vitamin D and DES. However, the available evidence for the association with other ocular diseases, such as glaucoma, TED, and RB, remains limited. |
format | Online Article Text |
id | pubmed-9032397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90323972022-04-23 Vitamin D and Ocular Diseases: A Systematic Review Chan, Hei-Nga Zhang, Xiu-Juan Ling, Xiang-Tian Bui, Christine Huyen-Trang Wang, Yu-Meng Ip, Patrick Chu, Wai-Kit Chen, Li-Jia Tham, Clement C. Yam, Jason C. Pang, Chi-Pui Int J Mol Sci Review The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), dry eye syndrome (DES), thyroid eye disease (TED), uveitis, retinoblastoma (RB), cataract, and others, from epidemiological, clinical and basic studies, and briefly discuss vitamin D metabolism in the eye. We searched two research databases for articles examining the association between vitamin D deficiency and different ocular diseases. One hundred and sixty-two studies were found. There is evidence on the association between vitamin D and myopia, AMD, DR, and DES. Overall, 17 out of 27 studies reported an association between vitamin D and AMD, while 48 out of 54 studies reported that vitamin D was associated with DR, and 25 out of 27 studies reported an association between vitamin D and DES. However, the available evidence for the association with other ocular diseases, such as glaucoma, TED, and RB, remains limited. MDPI 2022-04-11 /pmc/articles/PMC9032397/ /pubmed/35457041 http://dx.doi.org/10.3390/ijms23084226 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chan, Hei-Nga Zhang, Xiu-Juan Ling, Xiang-Tian Bui, Christine Huyen-Trang Wang, Yu-Meng Ip, Patrick Chu, Wai-Kit Chen, Li-Jia Tham, Clement C. Yam, Jason C. Pang, Chi-Pui Vitamin D and Ocular Diseases: A Systematic Review |
title | Vitamin D and Ocular Diseases: A Systematic Review |
title_full | Vitamin D and Ocular Diseases: A Systematic Review |
title_fullStr | Vitamin D and Ocular Diseases: A Systematic Review |
title_full_unstemmed | Vitamin D and Ocular Diseases: A Systematic Review |
title_short | Vitamin D and Ocular Diseases: A Systematic Review |
title_sort | vitamin d and ocular diseases: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032397/ https://www.ncbi.nlm.nih.gov/pubmed/35457041 http://dx.doi.org/10.3390/ijms23084226 |
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