Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice

Longevity of the immune response following viral exposure is an essential aspect of SARS-CoV-2 infection. Mild SARS-CoV-2 infection of K18-hACE2 mice was implemented for evaluating the mounting and longevity of a specific memory immune response. We show that the infection of K18-hACE2 mice induced r...

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Detalles Bibliográficos
Autores principales: Bar-On, Liat, Aftalion, Moshe, Makdasi, Efi, Gur, David, Alcalay, Ron, Cohen, Hila, Beth-Din, Adi, Rosenfeld, Ronit, Achdout, Hagit, Bar-Haim, Erez, Falach, Reut, Chitlaru, Theodor, Cohen, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032525/
https://www.ncbi.nlm.nih.gov/pubmed/35455362
http://dx.doi.org/10.3390/vaccines10040613
Descripción
Sumario:Longevity of the immune response following viral exposure is an essential aspect of SARS-CoV-2 infection. Mild SARS-CoV-2 infection of K18-hACE2 mice was implemented for evaluating the mounting and longevity of a specific memory immune response. We show that the infection of K18-hACE2 mice induced robust humoral and cellular immunity (systemic and local), which persisted for at least six months. Virus-specific T cells and neutralizing antibody titers decreased over time, yet their levels were sufficient to provide sterile immunity against lethal rechallenge six months post-primary infection. The study substantiates the role of naturally induced immunity against SARS-CoV-2 infection for preventing recurring morbidity.

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