Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice

Longevity of the immune response following viral exposure is an essential aspect of SARS-CoV-2 infection. Mild SARS-CoV-2 infection of K18-hACE2 mice was implemented for evaluating the mounting and longevity of a specific memory immune response. We show that the infection of K18-hACE2 mice induced r...

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Autores principales: Bar-On, Liat, Aftalion, Moshe, Makdasi, Efi, Gur, David, Alcalay, Ron, Cohen, Hila, Beth-Din, Adi, Rosenfeld, Ronit, Achdout, Hagit, Bar-Haim, Erez, Falach, Reut, Chitlaru, Theodor, Cohen, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032525/
https://www.ncbi.nlm.nih.gov/pubmed/35455362
http://dx.doi.org/10.3390/vaccines10040613
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author Bar-On, Liat
Aftalion, Moshe
Makdasi, Efi
Gur, David
Alcalay, Ron
Cohen, Hila
Beth-Din, Adi
Rosenfeld, Ronit
Achdout, Hagit
Bar-Haim, Erez
Falach, Reut
Chitlaru, Theodor
Cohen, Ofer
author_facet Bar-On, Liat
Aftalion, Moshe
Makdasi, Efi
Gur, David
Alcalay, Ron
Cohen, Hila
Beth-Din, Adi
Rosenfeld, Ronit
Achdout, Hagit
Bar-Haim, Erez
Falach, Reut
Chitlaru, Theodor
Cohen, Ofer
author_sort Bar-On, Liat
collection PubMed
description Longevity of the immune response following viral exposure is an essential aspect of SARS-CoV-2 infection. Mild SARS-CoV-2 infection of K18-hACE2 mice was implemented for evaluating the mounting and longevity of a specific memory immune response. We show that the infection of K18-hACE2 mice induced robust humoral and cellular immunity (systemic and local), which persisted for at least six months. Virus-specific T cells and neutralizing antibody titers decreased over time, yet their levels were sufficient to provide sterile immunity against lethal rechallenge six months post-primary infection. The study substantiates the role of naturally induced immunity against SARS-CoV-2 infection for preventing recurring morbidity.
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spelling pubmed-90325252022-04-23 Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice Bar-On, Liat Aftalion, Moshe Makdasi, Efi Gur, David Alcalay, Ron Cohen, Hila Beth-Din, Adi Rosenfeld, Ronit Achdout, Hagit Bar-Haim, Erez Falach, Reut Chitlaru, Theodor Cohen, Ofer Vaccines (Basel) Brief Report Longevity of the immune response following viral exposure is an essential aspect of SARS-CoV-2 infection. Mild SARS-CoV-2 infection of K18-hACE2 mice was implemented for evaluating the mounting and longevity of a specific memory immune response. We show that the infection of K18-hACE2 mice induced robust humoral and cellular immunity (systemic and local), which persisted for at least six months. Virus-specific T cells and neutralizing antibody titers decreased over time, yet their levels were sufficient to provide sterile immunity against lethal rechallenge six months post-primary infection. The study substantiates the role of naturally induced immunity against SARS-CoV-2 infection for preventing recurring morbidity. MDPI 2022-04-14 /pmc/articles/PMC9032525/ /pubmed/35455362 http://dx.doi.org/10.3390/vaccines10040613 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Bar-On, Liat
Aftalion, Moshe
Makdasi, Efi
Gur, David
Alcalay, Ron
Cohen, Hila
Beth-Din, Adi
Rosenfeld, Ronit
Achdout, Hagit
Bar-Haim, Erez
Falach, Reut
Chitlaru, Theodor
Cohen, Ofer
Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
title Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
title_full Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
title_fullStr Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
title_full_unstemmed Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
title_short Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
title_sort prolonged protective immunity induced by mild sars-cov-2 infection of k18-hace2 mice
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032525/
https://www.ncbi.nlm.nih.gov/pubmed/35455362
http://dx.doi.org/10.3390/vaccines10040613
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