Cargando…

Fucoxanthin Loaded in Palm Stearin- and Cholesterol-Based Solid Lipid Nanoparticle-Microcapsules, with Improved Stability and Bioavailability In Vivo

Fucoxanthin (FX) is a marine carotenoid that has proven to be a promising marine drug due to the multiple bioactivities it possesses. However, the instability and poor bioavailability of FX greatly limit its application in pharmaceuticals or functional foods. In this study, the creative construction...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yaxin, He, Niaoniao, Yang, Ting, Cai, Shuyun, Zhang, Yi, Lin, Jinjing, Huang, Mingqing, Chen, Weizhu, Zhang, Yiping, Hong, Zhuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032552/
https://www.ncbi.nlm.nih.gov/pubmed/35447909
http://dx.doi.org/10.3390/md20040237
_version_ 1784692671550324736
author Chen, Yaxin
He, Niaoniao
Yang, Ting
Cai, Shuyun
Zhang, Yi
Lin, Jinjing
Huang, Mingqing
Chen, Weizhu
Zhang, Yiping
Hong, Zhuan
author_facet Chen, Yaxin
He, Niaoniao
Yang, Ting
Cai, Shuyun
Zhang, Yi
Lin, Jinjing
Huang, Mingqing
Chen, Weizhu
Zhang, Yiping
Hong, Zhuan
author_sort Chen, Yaxin
collection PubMed
description Fucoxanthin (FX) is a marine carotenoid that has proven to be a promising marine drug due to the multiple bioactivities it possesses. However, the instability and poor bioavailability of FX greatly limit its application in pharmaceuticals or functional foods. In this study, the creative construction of a solid lipid nanoparticle-microcapsule delivery system using mixed lipids of palm stearin and cholesterol wrapped with gelatin/Arabic gum to load lipophilic FX was fabricated, aiming to improve the stability and bioavailability of FX. The results showed that the encapsulated efficiency (EE) and drug loading capacity (LC) of optimized FX microcapsules (FX-MCs) obtained were as high as 96.24 ± 4.60% and 0.85 ± 0.04%, respectively, after single-factor experiments. The average particle size was 1154 ± 54 nm with negative Zeta potential (−20.71 ± 0.93 mV) as depicted with size-zeta potential spectrometer. The differential scanning calorimeter (DSC) and thermogravimetric analyzer (TG) results indicated that FX-MC has a higher Tg and slower weight loss than FX monomers (FX crystal) and blank MCs. Besides, The Fourier transform infrared spectrometer (FTIR) confirmed the good double encapsulation of FX into the solid lipid and composite coacervate. Moreover, the encapsulated FX showed higher storage stability, sustained release (55.02 ± 2.80% release in 8 h), and significantly improved bioavailability (712.33%) when compared to free FX. The research results can provide a principle theoretical basis for the development and application of FX in pharmaceuticals or functional foods.
format Online
Article
Text
id pubmed-9032552
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90325522022-04-23 Fucoxanthin Loaded in Palm Stearin- and Cholesterol-Based Solid Lipid Nanoparticle-Microcapsules, with Improved Stability and Bioavailability In Vivo Chen, Yaxin He, Niaoniao Yang, Ting Cai, Shuyun Zhang, Yi Lin, Jinjing Huang, Mingqing Chen, Weizhu Zhang, Yiping Hong, Zhuan Mar Drugs Article Fucoxanthin (FX) is a marine carotenoid that has proven to be a promising marine drug due to the multiple bioactivities it possesses. However, the instability and poor bioavailability of FX greatly limit its application in pharmaceuticals or functional foods. In this study, the creative construction of a solid lipid nanoparticle-microcapsule delivery system using mixed lipids of palm stearin and cholesterol wrapped with gelatin/Arabic gum to load lipophilic FX was fabricated, aiming to improve the stability and bioavailability of FX. The results showed that the encapsulated efficiency (EE) and drug loading capacity (LC) of optimized FX microcapsules (FX-MCs) obtained were as high as 96.24 ± 4.60% and 0.85 ± 0.04%, respectively, after single-factor experiments. The average particle size was 1154 ± 54 nm with negative Zeta potential (−20.71 ± 0.93 mV) as depicted with size-zeta potential spectrometer. The differential scanning calorimeter (DSC) and thermogravimetric analyzer (TG) results indicated that FX-MC has a higher Tg and slower weight loss than FX monomers (FX crystal) and blank MCs. Besides, The Fourier transform infrared spectrometer (FTIR) confirmed the good double encapsulation of FX into the solid lipid and composite coacervate. Moreover, the encapsulated FX showed higher storage stability, sustained release (55.02 ± 2.80% release in 8 h), and significantly improved bioavailability (712.33%) when compared to free FX. The research results can provide a principle theoretical basis for the development and application of FX in pharmaceuticals or functional foods. MDPI 2022-03-29 /pmc/articles/PMC9032552/ /pubmed/35447909 http://dx.doi.org/10.3390/md20040237 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Yaxin
He, Niaoniao
Yang, Ting
Cai, Shuyun
Zhang, Yi
Lin, Jinjing
Huang, Mingqing
Chen, Weizhu
Zhang, Yiping
Hong, Zhuan
Fucoxanthin Loaded in Palm Stearin- and Cholesterol-Based Solid Lipid Nanoparticle-Microcapsules, with Improved Stability and Bioavailability In Vivo
title Fucoxanthin Loaded in Palm Stearin- and Cholesterol-Based Solid Lipid Nanoparticle-Microcapsules, with Improved Stability and Bioavailability In Vivo
title_full Fucoxanthin Loaded in Palm Stearin- and Cholesterol-Based Solid Lipid Nanoparticle-Microcapsules, with Improved Stability and Bioavailability In Vivo
title_fullStr Fucoxanthin Loaded in Palm Stearin- and Cholesterol-Based Solid Lipid Nanoparticle-Microcapsules, with Improved Stability and Bioavailability In Vivo
title_full_unstemmed Fucoxanthin Loaded in Palm Stearin- and Cholesterol-Based Solid Lipid Nanoparticle-Microcapsules, with Improved Stability and Bioavailability In Vivo
title_short Fucoxanthin Loaded in Palm Stearin- and Cholesterol-Based Solid Lipid Nanoparticle-Microcapsules, with Improved Stability and Bioavailability In Vivo
title_sort fucoxanthin loaded in palm stearin- and cholesterol-based solid lipid nanoparticle-microcapsules, with improved stability and bioavailability in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032552/
https://www.ncbi.nlm.nih.gov/pubmed/35447909
http://dx.doi.org/10.3390/md20040237
work_keys_str_mv AT chenyaxin fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT heniaoniao fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT yangting fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT caishuyun fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT zhangyi fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT linjinjing fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT huangmingqing fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT chenweizhu fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT zhangyiping fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo
AT hongzhuan fucoxanthinloadedinpalmstearinandcholesterolbasedsolidlipidnanoparticlemicrocapsuleswithimprovedstabilityandbioavailabilityinvivo