Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma

SIMPLE SUMMARY: Multiple myeloma is a non-curable disease and new therapeutic approaches are needed. PAPTP and PCARBTP, two novel mitochondria-specific inhibitors of the Kv1.3 ion channel, are effective in killing cultured myeloma cell lines and myeloma cells isolated from patient punctates, while h...

Descripción completa

Detalles Bibliográficos
Autores principales: Kadow, Stephanie, Schumacher, Fabian, Kramer, Melanie, Hessler, Gabriele, Scholtysik, René, Oubari, Sara, Johansson, Patricia, Hüttmann, Andreas, Reinhardt, Hans Christian, Kleuser, Burkhard, Zoratti, Mario, Mattarei, Andrea, Szabò, Ildiko, Gulbins, Erich, Carpinteiro, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032553/
https://www.ncbi.nlm.nih.gov/pubmed/35454865
http://dx.doi.org/10.3390/cancers14081955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032553/
https://www.ncbi.nlm.nih.gov/pubmed/35454865
http://dx.doi.org/10.3390/cancers14081955

Ejemplares similares