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Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial

As frailty in older patients with acute heart failure (AHF) has an adverse effect on clinical outcomes, the addition of electrical muscle stimulation (EMS) to exercise-based early rehabilitation may improve the effects of treatment. Post hoc analysis was performed on a randomized controlled study fo...

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Autores principales: Tanaka, Shinya, Kamiya, Kentaro, Matsue, Yuya, Yonezawa, Ryusuke, Saito, Hiroshi, Hamazaki, Nobuaki, Matsuzawa, Ryota, Nozaki, Kohei, Yamashita, Masashi, Wakaume, Kazuki, Endo, Yoshiko, Maekawa, Emi, Yamaoka-Tojo, Minako, Shiono, Takaaki, Inomata, Takayuki, Ako, Junya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032621/
https://www.ncbi.nlm.nih.gov/pubmed/35448075
http://dx.doi.org/10.3390/jcdd9040099
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author Tanaka, Shinya
Kamiya, Kentaro
Matsue, Yuya
Yonezawa, Ryusuke
Saito, Hiroshi
Hamazaki, Nobuaki
Matsuzawa, Ryota
Nozaki, Kohei
Yamashita, Masashi
Wakaume, Kazuki
Endo, Yoshiko
Maekawa, Emi
Yamaoka-Tojo, Minako
Shiono, Takaaki
Inomata, Takayuki
Ako, Junya
author_facet Tanaka, Shinya
Kamiya, Kentaro
Matsue, Yuya
Yonezawa, Ryusuke
Saito, Hiroshi
Hamazaki, Nobuaki
Matsuzawa, Ryota
Nozaki, Kohei
Yamashita, Masashi
Wakaume, Kazuki
Endo, Yoshiko
Maekawa, Emi
Yamaoka-Tojo, Minako
Shiono, Takaaki
Inomata, Takayuki
Ako, Junya
author_sort Tanaka, Shinya
collection PubMed
description As frailty in older patients with acute heart failure (AHF) has an adverse effect on clinical outcomes, the addition of electrical muscle stimulation (EMS) to exercise-based early rehabilitation may improve the effects of treatment. Post hoc analysis was performed on a randomized controlled study for clinical outcomes and prespecified subgroups (ACTIVE-EMS: UMIN000019551). In this trial, 31 AHF patients aged ≥ 75 years with frailty (Short Physical Performance Battery [SPPB] score 4–9) were randomized 1:1 to receive treatment with an early rehabilitation program only (n = 16) or early rehabilitation with add-on EMS therapy (n = 15) for 2 weeks. Changes in physical function and cognitive function between baseline and after two weeks of treatment were assessed. There were no adverse events during the EMS period. The EMS group showed significantly greater changes in quadriceps’ isometric strength and SPPB compared to the control group, and EMS therapy showed uniform effects in the prespecified subgroups. There were no significant differences in the changes in other indexes of physical function and cognitive function between groups. There was no significant difference in the rate of heart failure hospitalization at 90 days between groups. In conclusion, older AHF patients with frailty showed greater improvement in lower extremity function with the addition of EMS therapy to early rehabilitation without adverse events.
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spelling pubmed-90326212022-04-23 Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial Tanaka, Shinya Kamiya, Kentaro Matsue, Yuya Yonezawa, Ryusuke Saito, Hiroshi Hamazaki, Nobuaki Matsuzawa, Ryota Nozaki, Kohei Yamashita, Masashi Wakaume, Kazuki Endo, Yoshiko Maekawa, Emi Yamaoka-Tojo, Minako Shiono, Takaaki Inomata, Takayuki Ako, Junya J Cardiovasc Dev Dis Article As frailty in older patients with acute heart failure (AHF) has an adverse effect on clinical outcomes, the addition of electrical muscle stimulation (EMS) to exercise-based early rehabilitation may improve the effects of treatment. Post hoc analysis was performed on a randomized controlled study for clinical outcomes and prespecified subgroups (ACTIVE-EMS: UMIN000019551). In this trial, 31 AHF patients aged ≥ 75 years with frailty (Short Physical Performance Battery [SPPB] score 4–9) were randomized 1:1 to receive treatment with an early rehabilitation program only (n = 16) or early rehabilitation with add-on EMS therapy (n = 15) for 2 weeks. Changes in physical function and cognitive function between baseline and after two weeks of treatment were assessed. There were no adverse events during the EMS period. The EMS group showed significantly greater changes in quadriceps’ isometric strength and SPPB compared to the control group, and EMS therapy showed uniform effects in the prespecified subgroups. There were no significant differences in the changes in other indexes of physical function and cognitive function between groups. There was no significant difference in the rate of heart failure hospitalization at 90 days between groups. In conclusion, older AHF patients with frailty showed greater improvement in lower extremity function with the addition of EMS therapy to early rehabilitation without adverse events. MDPI 2022-03-27 /pmc/articles/PMC9032621/ /pubmed/35448075 http://dx.doi.org/10.3390/jcdd9040099 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tanaka, Shinya
Kamiya, Kentaro
Matsue, Yuya
Yonezawa, Ryusuke
Saito, Hiroshi
Hamazaki, Nobuaki
Matsuzawa, Ryota
Nozaki, Kohei
Yamashita, Masashi
Wakaume, Kazuki
Endo, Yoshiko
Maekawa, Emi
Yamaoka-Tojo, Minako
Shiono, Takaaki
Inomata, Takayuki
Ako, Junya
Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial
title Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial
title_full Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial
title_fullStr Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial
title_full_unstemmed Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial
title_short Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial
title_sort efficacy and safety of acute phase intensive electrical muscle stimulation in frail older patients with acute heart failure: results from the active-ems trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032621/
https://www.ncbi.nlm.nih.gov/pubmed/35448075
http://dx.doi.org/10.3390/jcdd9040099
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