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Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea

Safety issues regarding the potential risk of statins and incident rheumatoid arthritis (RA) have been raised, but the existing data are largely based on Caucasian populations, and continue to have biases and require further validation in Asian populations. Here, we aimed to verify the risk of RA de...

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Autores principales: Kwon, Mi Jung, Kim, Joo-Hee, Kim, Ji Hee, Park, Hye-Rim, Kim, Nan Young, Hong, Sangkyoon, Choi, Hyo Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032630/
https://www.ncbi.nlm.nih.gov/pubmed/35455675
http://dx.doi.org/10.3390/jpm12040559
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author Kwon, Mi Jung
Kim, Joo-Hee
Kim, Ji Hee
Park, Hye-Rim
Kim, Nan Young
Hong, Sangkyoon
Choi, Hyo Geun
author_facet Kwon, Mi Jung
Kim, Joo-Hee
Kim, Ji Hee
Park, Hye-Rim
Kim, Nan Young
Hong, Sangkyoon
Choi, Hyo Geun
author_sort Kwon, Mi Jung
collection PubMed
description Safety issues regarding the potential risk of statins and incident rheumatoid arthritis (RA) have been raised, but the existing data are largely based on Caucasian populations, and continue to have biases and require further validation in Asian populations. Here, we aimed to verify the risk of RA depending on the duration of previous statin use and statin types using a large-scale, nationwide database. This study enrolled 3149 patients with RA and 12,596 matched non-RA participants from the national health insurance database (2002–2015), and investigated their statin prescription histories for two years before the index date. Propensity score overlap-weighted logistic regression was applied after adjusting for multiple covariates. The prior use of any statins and, specifically, the long-term use of lipophilic statins (>365 days) were related to a lower likelihood of developing RA ((odds ratio (OR) = 0.73; 95% confidence intervals (CI) = 0.63–0.85, p < 0.001) and (OR = 0.71; 95% CI = 0.61–0.84, p < 0.001), respectively). Subgroup analyses supported these preventive effects on RA in those with dyslipidemia, independent of sex, age, smoking, alcohol use, hypertension, and hyperglycemia. Hydrophilic statin use or short-term use showed no such associations. Our study suggests that prior statin use, especially long-term lipophilic statin use, appears to confer preventive benefits against RA.
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spelling pubmed-90326302022-04-23 Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea Kwon, Mi Jung Kim, Joo-Hee Kim, Ji Hee Park, Hye-Rim Kim, Nan Young Hong, Sangkyoon Choi, Hyo Geun J Pers Med Article Safety issues regarding the potential risk of statins and incident rheumatoid arthritis (RA) have been raised, but the existing data are largely based on Caucasian populations, and continue to have biases and require further validation in Asian populations. Here, we aimed to verify the risk of RA depending on the duration of previous statin use and statin types using a large-scale, nationwide database. This study enrolled 3149 patients with RA and 12,596 matched non-RA participants from the national health insurance database (2002–2015), and investigated their statin prescription histories for two years before the index date. Propensity score overlap-weighted logistic regression was applied after adjusting for multiple covariates. The prior use of any statins and, specifically, the long-term use of lipophilic statins (>365 days) were related to a lower likelihood of developing RA ((odds ratio (OR) = 0.73; 95% confidence intervals (CI) = 0.63–0.85, p < 0.001) and (OR = 0.71; 95% CI = 0.61–0.84, p < 0.001), respectively). Subgroup analyses supported these preventive effects on RA in those with dyslipidemia, independent of sex, age, smoking, alcohol use, hypertension, and hyperglycemia. Hydrophilic statin use or short-term use showed no such associations. Our study suggests that prior statin use, especially long-term lipophilic statin use, appears to confer preventive benefits against RA. MDPI 2022-04-01 /pmc/articles/PMC9032630/ /pubmed/35455675 http://dx.doi.org/10.3390/jpm12040559 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kwon, Mi Jung
Kim, Joo-Hee
Kim, Ji Hee
Park, Hye-Rim
Kim, Nan Young
Hong, Sangkyoon
Choi, Hyo Geun
Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea
title Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea
title_full Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea
title_fullStr Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea
title_full_unstemmed Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea
title_short Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea
title_sort incident rheumatoid arthritis following statin use: from the view of a national cohort study in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032630/
https://www.ncbi.nlm.nih.gov/pubmed/35455675
http://dx.doi.org/10.3390/jpm12040559
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