Cargando…

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central nervous system (CNS) reservoir. This requires a deep understanding of the molecular mechanisms of HIV’s entry into the CNS, latency establishment,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gumbs, Stephanie B. H., Berdenis van Berlekom, Amber, Kübler, Raphael, Schipper, Pauline J., Gharu, Lavina, Boks, Marco P., Ormel, Paul R., Wensing, Annemarie M. J., de Witte, Lot D., Nijhuis, Monique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032670/ https://www.ncbi.nlm.nih.gov/pubmed/35458559 http://dx.doi.org/10.3390/v14040829

Ejemplares similares

Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analyses
por: Gumbs, Stephanie B. H., et al.
Publicado: (2022)

Microglia innately develop within cerebral organoids
por: Ormel, Paul R., et al.
Publicado: (2018)

Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model
por: Berdenis van Berlekom, Amber, et al.
Publicado: (2022)

Shock and kill within the CNS: A promising HIV eradication approach?
por: Nühn, Marieke M., et al.
Publicado: (2022)

Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated
por: Sneeboer, Marjolein A. M., et al.
Publicado: (2019)

Genetic analysis of the human microglia transcriptome across brain regions, aging and disease pathologies
por: de Paiva Lopes, Katia, et al.
Publicado: (2022)

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies
por: Berdenis van Berlekom, Amber, et al.
Publicado: (2020)

Use of dolutegravir in two INI-experienced patients with multiclass resistance resulted in excellent virological and immunological responses
por: Marije Hofstra, Laura, et al.
Publicado: (2014)

A loss of mature microglial markers without immune activation in schizophrenia
por: Snijders, Gijsje J. L. J., et al.
Publicado: (2021)

Microglia-containing human brain organoids for the study of brain development and pathology
por: Zhang, Wendiao, et al.
Publicado: (2022)

Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases
por: Hong, Yiling, et al.
Publicado: (2023)

Human Immunodeficiency Virus gag and protease: partners in resistance
por: Fun, Axel, et al.
Publicado: (2012)

Post transcriptional regulation of HIV-1 gene expression by MATR3, PSF and Rev
por: Gharu, Lavina, et al.
Publicado: (2013)

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids
por: Fagerlund, Ilkka, et al.
Publicado: (2021)

Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids From Human Induced Pluripotent Stem Cells
por: Bodnar, Brittany, et al.
Publicado: (2021)

Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance
por: Fun, Axel, et al.
Publicado: (2018)

Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids
por: Popova, Galina, et al.
Publicado: (2023)

Clinical Use of HIV Integrase Inhibitors: A Systematic Review and Meta-Analysis
por: Messiaen, Peter, et al.
Publicado: (2013)

Modeling Brain Somatic Mosaicism With Cerebral Organoids, Including a Note on Mutant Microglia
por: Verheijen, Bert M.
Publicado: (2019)

Childhood Adversity Is Associated With Increased KITLG Methylation in Healthy Individuals but Not in Bipolar Disorder Patients
por: He, Yujie, et al.
Publicado: (2019)

Retraction: Modeling Brain Somatic Mosaicism With Cerebral Organoids, Including a Note on Mutant Microglia
Publicado: (2020)

Cerebral organoids containing an AUTS2 missense variant model microcephaly
por: Fair, Summer R, et al.
Publicado: (2022)

An inkjet-printed polysaccharide matrix for on-chip sample preparation in point-of-care cell counting chambers
por: Zhang, Xichen, et al.
Publicado: (2020)

Residual Viremia Is Preceding Viral Blips and Persistent Low-Level Viremia in Treated HIV-1 Patients
por: Hofstra, Laura Marije, et al.
Publicado: (2014)

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
por: Sabate‐Soler, Sonia, et al.
Publicado: (2022)

Diminished transmission of drug resistant HIV-1 variants with reduced replication capacity in a human transmission model
por: Pingen, Marieke, et al.
Publicado: (2014)

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat
por: Fun, Axel, et al.
Publicado: (2011)

PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids
por: Shiraki, Nobuhiko, et al.
Publicado: (2022)

A systematic characterization of microglia-like cell occurrence during retinal organoid differentiation
por: Bartalska, Katarina, et al.
Publicado: (2022)

Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology
por: Xu, Ranjie, et al.
Publicado: (2021)

Evaluation of a commercial SARS-CoV-2 multiplex PCR genotyping assay for variant identification in resource-scarce settings
por: Umunnakwe, Chijioke N., et al.
Publicado: (2022)

Characterization of macrophages from schizophrenia patients
por: Ormel, Paul R., et al.
Publicado: (2017)

Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies
por: Stam, Jord C., et al.
Publicado: (2022)

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids
por: Chichagova, Valeria, et al.
Publicado: (2023)

Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression
por: Böttcher, Chotima, et al.
Publicado: (2020)

Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity
por: van Maarseveen, Noortje M, et al.
Publicado: (2012)

Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
por: Cakir, Bilal, et al.
Publicado: (2022)

The moral status of cerebral organoids
por: Hostiuc, Sorin, et al.
Publicado: (2019)

Analysis of Synapses in Cerebral Organoids
por: Yakoub, Abraam M., et al.
Publicado: (2019)

Point-of-Care Tenofovir Urine Testing for the Prediction of Treatment Failure and Drug Resistance During Initial Treatment for Human Immunodeficiency Virus Type 1 (HIV-1) Infection
por: Hermans, Lucas E, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8s91trnpn73ljuocuifuf08i1f